8pnm

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Structure of human KCTD15 BTB domain mutant G88D crystal form 2

Structural highlights

8pnm is a 12 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.94Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KCD15_HUMAN During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain.[1]

References

  1. ↑ Zarelli VE, Dawid IB. Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2870-5. PMID:23382213 doi:10.1073/pnas.1300203110

Contents


PDB ID 8pnm

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OCA

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