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8qjx

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Human Adenovirus type 11 fiber knob in complex with two copies of its cell receptor, Desmoglein-2

Structural highlights

8qjx is a 5 chain structure with sequence from Homo sapiens and Human adenovirus 11. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.3Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SPIKE_ADE1P Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CD46 to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface.

Publication Abstract from PubMed

The main limitation of oncolytic vectors is neutralization by blood components, which prevents intratumoral administration to patients. Enadenotucirev, a chimeric HAdV-11p/HAdV-3 adenovirus identified by bio-selection, is a low seroprevalence vector active against a broad range of human carcinoma cell lines. At this stage, there's still some uncertainty about tropism and primary receptor utilization by HAdV-11. However, this information is very important, as it has a direct influence on the effectiveness of HAdV-11-based vectors. The aim of this work is to determine which of the two receptors, DSG2 and CD46, is involved in the attachment of the virus to the host, and what role they play in the early stages of infection.

Toward the understanding of DSG2 and CD46 interaction with HAdV-11 fiber, a super-complex analysis.,Effantin G, Hograindleur M-A, Fenel D, Fender P, Vassal-Stermann E J Virol. 2023 Nov 30;97(11):e0091023. doi: 10.1128/jvi.00910-23. Epub 2023 Nov 3. PMID:37921471^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Effantin G, Hograindleur M-A, Fenel D, Fender P, Vassal-Stermann E. Toward the understanding of DSG2 and CD46 interaction with HAdV-11 fiber, a super-complex analysis. J Virol. 2023 Nov 30;97(11):e0091023. PMID:37921471 doi:10.1128/jvi.00910-23