8sjx

From Proteopedia

Structure of lens aquaporin-0 array in sphingomyelin/cholesterol bilayer (2SM:1Chol)

Structural highlights

8sjx is a 1 chain structure with sequence from Ovis aries. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron crystallography, Resolution 2.5Å
Ligands:	CLR, HWP
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MIP_SHEEP Water channel. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.^[1] ^[2] ^[3]

References

↑ Gonen T, Sliz P, Kistler J, Cheng Y, Walz T. Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature. 2004 May 13;429(6988):193-7. PMID:15141214 doi:10.1038/nature02503
↑ Gonen T, Cheng Y, Kistler J, Walz T. Aquaporin-0 membrane junctions form upon proteolytic cleavage. J Mol Biol. 2004 Sep 24;342(4):1337-45. PMID:15351655 doi:http://dx.doi.org/10.1016/j.jmb.2004.07.076
↑ Hite RK, Li Z, Walz T. Principles of membrane protein interactions with annular lipids deduced from aquaporin-0 2D crystals. EMBO J. 2010 May 19;29(10):1652-8. Epub 2010 Apr 13. PMID:20389283 doi:10.1038/emboj.2010.68

1 Structural highlights
2 Function
3 References

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PDB ID 8sjx

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Categories: Large Structures | Ovis aries | Chiu P-L | Walz T

8sjx

From Proteopedia

Structure of lens aquaporin-0 array in sphingomyelin/cholesterol bilayer (2SM:1Chol)

Structural highlights

Function

References

Contents

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