8tg9

From Proteopedia

Complex of NPR1 ectodomain with ANP plus an allosteric activating antibody, REGN5381

Structural highlights

8tg9 is a 7 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.08Å
Ligands:	BMA, MAN, NAG
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ANPRA_HUMAN Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.^[1]

References

↑ Koller KJ, Lowe DG, Bennett GL, Minamino N, Kangawa K, Matsuo H, Goeddel DV. Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). Science. 1991 Apr 5;252(5002):120-3. PMID:1672777

1 Structural highlights
2 Function
3 References

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PDB ID 8tg9

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Categories: Homo sapiens | Large Structures | Mus musculus | Franklin MC | Romero Hernandez A

8tg9

From Proteopedia

Complex of NPR1 ectodomain with ANP plus an allosteric activating antibody, REGN5381

Structural highlights

Function

References

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