8v75

From Proteopedia

Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with compound 11

Structural highlights

8v75 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.85Å
Ligands:	SO4, YIK
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IPMK_HUMAN Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4).^[1] ^[2]

References

↑ Nalaskowski MM, Deschermeier C, Fanick W, Mayr GW. The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization. Biochem J. 2002 Sep 1;366(Pt 2):549-56. PMID:12027805 doi:http://dx.doi.org/10.1042/BJ20020327
↑ Chang SC, Miller AL, Feng Y, Wente SR, Majerus PW. The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase. J Biol Chem. 2002 Nov 15;277(46):43836-43. Epub 2002 Sep 9. PMID:12223481 doi:http://dx.doi.org/10.1074/jbc.M206134200

1 Structural highlights
2 Function
3 References

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PDB ID 8v75

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Categories: Homo sapiens | Large Structures | Shears SB | Wang H

8v75

From Proteopedia

Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with compound 11

Structural highlights

Function

References

Contents

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