8x81

Structural highlights

Disease

LEPR_HUMAN Obesity due to leptin receptor gene deficiency. The disease is caused by mutations affecting the gene represented in this entry.

Function

LEPR_HUMAN Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).