8xsb

From Proteopedia

Jump to: navigation, search

Crystal structure of the DNA-bound AHR-ARNT heterodimer in complex with Indirubin

Structural highlights

8xsb is a 4 chain structure with sequence from Homo sapiens and Sus scrofa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.06Å
Ligands:JY6
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ARNT_HUMAN Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.

Contents


PDB ID 8xsb

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://proteopedia.org/wiki/index.php/8xsb"
Personal tools