Structural highlights
Function
GCVA_ECOLI Regulatory protein for the glycine cleavage system operon (gcv). Mediates activation of gcv by glycine and repression by purines. GcvA is negatively autoregulated. Binds to three sites upstream of the gcv promoter.
Publication Abstract from PubMed
Although structures of many RNA loops, such as GNRA and UNCG tetraloops, were well known, it is still possible to find more RNA structures. In the present study, solution structure of an RNA fragment having UUCGA pentaloop was analyzed by NMR spectroscopy. It was found that the UUCG tetraloop is formed and the adenosine residue at the 3' side of the tetraloop is bulged out. The characteristic motif of the loop-bulge structure has also been found in other RNAs including CUUGU and CUGGC pentaloops. Along with the recently found T-hairpin structure with a UUUGAUU loop, in which UUUGA pentaloop and UU bulge are formed, the loop-bulge structures can be categorized as an RNA motif and it may be called as the integrated structure loop, I-loop.
NMR analysis of a loop-bulge structure of UUCGA pentaloop.,Ichijo R, Kawai G Biochem Biophys Res Commun. 2024 Jan 8;691:149327. doi: , 10.1016/j.bbrc.2023.149327. Epub 2023 Nov 25. PMID:38039839[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Ichijo R, Kawai G. NMR analysis of a loop-bulge structure of UUCGA pentaloop. Biochem Biophys Res Commun. 2024 Jan 8;691:149327. PMID:38039839 doi:10.1016/j.bbrc.2023.149327
