8yar

Structural highlights

Function

TBA3_CAEEL Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Component of the large-diameter neuronal microtubules which contains 15 protofilaments (PubMed:9885292). Plays a role in mechanosensory transduction (touch sensitivity) (PubMed:19652181, PubMed:9885292).^{[1] [2]}

References

1. ↑ Bounoutas A, Zheng Q, Nonet ML, Chalfie M. mec-15 encodes an F-box protein required for touch receptor neuron mechanosensation, synapse formation and development. Genetics. 2009 Oct;183(2):607-17, 1SI-4SI. PMID:19652181 doi:10.1534/genetics.109.105726
2. ↑ Fukushige T, Siddiqui ZK, Chou M, Culotti JG, Gogonea CB, Siddiqui SS, Hamelin M. MEC-12, an alpha-tubulin required for touch sensitivity in C. elegans. J Cell Sci. 1999 Feb;112 ( Pt 3):395-403. PMID:9885292 doi:10.1242/jcs.112.3.395