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9el1

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ML2-SA1/PI(3,5)P2 bound TRPML2 in an open state

Structural highlights

9el1 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 2.61Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MCLN2_HUMAN Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19940139, PubMed:19885840). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840).[UniProtKB:Q8K595]^[1] ^[2] ^[3]

References

↑ Karacsonyi C, Miguel AS, Puertollano R. Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APs. Traffic. 2007 Oct;8(10):1404-14. doi: 10.1111/j.1600-0854.2007.00619.x. Epub 2007, Jul 29. PMID:17662026 doi:http://dx.doi.org/10.1111/j.1600-0854.2007.00619.x
↑ Curcio-Morelli C, Zhang P, Venugopal B, Charles FA, Browning MF, Cantiello HF, Slaugenhaupt SA. Functional multimerization of mucolipin channel proteins. J Cell Physiol. 2010 Feb;222(2):328-35. doi: 10.1002/jcp.21956. PMID:19885840 doi:http://dx.doi.org/10.1002/jcp.21956
↑ Lev S, Zeevi DA, Frumkin A, Offen-Glasner V, Bach G, Minke B. Constitutive activity of the human TRPML2 channel induces cell degeneration. J Biol Chem. 2010 Jan 22;285(4):2771-82. doi: 10.1074/jbc.M109.046508. Epub 2009 , Nov 23. PMID:19940139 doi:http://dx.doi.org/10.1074/jbc.M109.046508