Alpha-tubulin N-acetyltransferase (TAT) catalyzes the conversion of acetyl-CoA and tubulin-L-lysine to CoA and tubulin-N-acetyl-L-lysine. TAT acetylates Lys40 in tubulin and is required for normal sperm flagellar function. This posttranslational modification of tubulin is conserved in long-lived microtubules. TAT can acetylate itself and this acts as a regulatory mechanism for its action on tubulin.[1]
of α-tubulin N-acetyltransferase (PDB code 3vwe).[2] Water molecules are shown as red spheres.
3D Structures of alpha-tubulin N-acetyltransferase
Alpha-tubulin N-acetyltransferase 3D structures
