Bcr-Abl and Imatinib (STI571 or Gleevec)

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c-Abl tyrosine kinase: SH3 domain is shown in red while SH2 domain is shown in purple. The catalytic domain is represented in blue. It is also possible to observe myristoyl group in the N-terminal domain of c-Abl tyrosine kinase (PDB code 1opk)

3D structures

Tyrosine kinase

Authors

Almudena Chaves Pérez; Julio César Corral Serrano; Cristina Murga Montesinos.

Some morphs and scenes were reproduced from the pages of David Canner. We acknowledge the help of Elisa Lucas.

References

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Michal Harel, Alexander Berchansky, Joel L. Sussman, Cristina Murga

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