Function
Beta-N-acetylhexosaminidase or Beta-hexosaminidase or chitobiase (BNAHEX) is a glycoside hydrolase catalysing the cleavage of GlcNAc and GalNAc [1]. BNAHEX serves as a biosynthetic tool for the preparation of hexosaminides under mild conditions. See also Beta-Hexosaminidase.
Disease
Elevated levels of BNAHEX were found in patients wit Tay-Sachs disease[2].
Relevance
BVAHEX is a target for the design of agricultural fungicides[3].
Structural highlights
The 3D structure of beta-N-acetylhexosaminidase complex with the inhibitor berberine shows the berberine forming interaction with W490. The active site includes a interacting with berberine[4]. . Water molecules are shown as red spheres.
3D structures of beta-N-acetylhexosaminidase
Beta-N-acetylhexosaminidase 3D structures