Function
Beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase or 3-oxoacyl-ACP reductase (FabZ) catalyzes the dehydration of short and long chained β-hydroxyacyl-ACPs.
- FabA exhibits broad overlapping activity to FabZ and is most active in dehydrating midlength chained β-hydroxyacyl-ACPs.
- FabG or 3-ketoacyl-(acyl-carrier-protein) reductase or beta-ketoacyl carrier protein reductase is part of the fatty acid biosythesis elongation cycle. FabG reduces the β-keto acyl group of the elongating fatty acid[1].
See also: Fatty acid synthesis
Structural highlights
. This tunnel accommodates the substrate. [2]
3D structures of β-hydroxyacyl-acyl carrier protein dehydratase
Beta-hydroxyacyl-acyl carrier protein dehydratase 3D structures
