Bone morphogenetic protein

From Proteopedia

Contents 1 Function 2 Relevance 3 Disease 4 3D structures of bone morphogenetic protein Function Bone morphogenetic protein (BMP) are growth factors which can induce formation of bone and cartllage'[1]. Over 20 BMPs are known at present. BMP is part of the Transforming Growth Factor-β (TGF-β) family of proteins. BMP-1 cleaves the C-propeptides of type I pro collagen during the synthesis of extracellular collagen fibrils[2]. BMP-2 has important role in embryogenesis, bone formation and homeostasis[3]. BMP-3 is a major component in osteogenin[4]. BMP-6 is essential for expression of hepcidin which controls iron homeostasis[5]. BMP-7 is a major role in embryogenesis, skeletal morphogenesis and neurogenesis[6]. For details on BMP-7 see Student Projects for UMass Chemistry 423 Spring 2012-4. BMP-9, BMP-11 and Placental BMP-15 see Growth differentiation factor BMP-10 is cardiac-specific inducing trophoblast differentiation in stem cells[7]. See also Growth factors, Enzyme-linked receptor Growth differentiation factor TGF beta signaling pathway. Relevance Recombinant BMP is used in oral surgery and spinal fusion. Disease BMP-7 is involved in chronic kidney disease[8]. 3D structures of bone morphogenetic protein Bone morphogenetic protein 3D structures

spinqualitylabelsall models Human BMP-2 (grey and green) complex with BMP receptor extracellular domain (yellow and pink) (PDB entry 2qja) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

References

1. ↑ Reddi AH, Reddi A. Bone morphogenetic proteins (BMPs): from morphogens to metabologens. Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):341-2. doi:, 10.1016/j.cytogfr.2009.10.015. Epub 2009 Nov 8. PMID:19900831 doi:http://dx.doi.org/10.1016/j.cytogfr.2009.10.015
2. ↑ Hartigan N, Garrigue-Antar L, Kadler KE. Bone morphogenetic protein-1 (BMP-1). Identification of the minimal domain structure for procollagen C-proteinase activity. J Biol Chem. 2003 May 16;278(20):18045-9. PMID:12637537 doi:10.1074/jbc.M211448200
3. ↑ Halloran D, Durbano HW, Nohe A. Bone Morphogenetic Protein-2 in Development and Bone Homeostasis. J Dev Biol. 2020 Sep 13;8(3):19. PMID:32933207 doi:10.3390/jdb8030019
4. ↑ Bahamonde ME, Lyons KM. BMP3: to be or not to be a BMP. J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 1):S56-62 PMID:11263666
5. ↑ Wang S, Chen C, Yu L, Mueller J, Rausch V, Mueller S. Bone morphogenetic protein 6-mediated crosstalk between endothelial cells and hepatocytes recapitulates the iron-sensing pathway in vitro. J Biol Chem. 2021 Dec;297(6):101378. PMID:34740612 doi:10.1016/j.jbc.2021.101378
6. ↑ Aluganti Narasimhulu C, Singla DK. The Role of Bone Morphogenetic Protein 7 (BMP-7) in Inflammation in Heart Diseases. Cells. 2020 Jan 23;9(2):280. PMID:31979268 doi:10.3390/cells9020280
7. ↑ Lichtner B, Knaus P, Lehrach H, Adjaye J. BMP10 as a potent inducer of trophoblast differentiation in human embryonic and induced pluripotent stem cells. Biomaterials. 2013 Dec;34(38):9789-802. PMID:24070570 doi:10.1016/j.biomaterials.2013.08.084
8. ↑ Mitu G, Hirschberg R. Bone morphogenetic protein-7 (BMP7) in chronic kidney disease. Front Biosci. 2008 May 1;13:4726-39. PMID:18508541