Bromodomain-containing protein 3D structures

2ku3 – hBRD1 PHD1 zinc finger domain - human - NMR

2lq6 – hBRD1 PHD2 zinc finger domain (mutant) - NMR

3l43 – histone H3.3 N-terminal/hBRD1 PHD1 zinc finger domain - NMR

3rcw, 4z02 – hBRD1 bromodomain

5pwb, 5pwa, 5pw9, 5pw8, 5pw7, 5pw6, 5pw5, 5pw4, 5pw3, 5pw2, 5pw1, 5pw0, 5pvz, 5pvy, 5pvx, 5pvw, 5pvv, 5pvu, 5pvt, 5pvs, 5pvr, 5pvq, 5pvp, 5pvo, 5pvn, 5pvm, 5pvl, 5pvk, 5pvj, 5pvi, 5pvh, 5pvg, 5pvf, 5pve, 5pvd, 5pvc, 5pvb, 5pva, 5pv9, 5pv8, 5pv7, 5pv6, 5pv5, 5pv4, 5pv3, 5pv2, 5pv1, 5pv0, 5puz, 5puy, 5pux, 5puw, 5puv, 5puu, 5put, 5pus, 5pur, 5puq, 5pup, 5pun, 5pum, 5puo, 5pul, 5puk, 5puj, 5pui, 5puh, 5pug, 5puf, 5pue, 5pud, 5puc, 5pub, 5pua, 5pu9, 5pu8, 5pu7, 5pu6, 5pu5, 5pu4, 5pu3, 5pu2, 5pu1, 5pu0, 5ptz, 5pty, 5ptx, 5ptw, 5ptv, 5ptu, 5pts, 5ptt, 5ptr, 5ptq, 5ptp, 5pto, 5ptn, 5ptm, 5ptl, 5ptk, 5ptj, 5pth, 5ptg, 5ptf, 5pte, 5ptd, 5ptc, 5ptb, 5pta, 5pt9, 5pt8, 5pt7, 5pt0, 5pt1, 5pt2, 5pt3, 5pt4, 5pt5, 5pt6, 5pnx, 5pq0, 5pq1, 5pq2, 5pq3, 5pq4, 5pq5, 5pq6, 5pq7, 5pq8, 5pq9, 5pqa, 5pqb, 5pqc, 5pqd, 5pqe, 5pqf, 5pqg, 5pqh, 5pqi, 5pqj, 5pqk, 5pql, 5pqm, 5pqn, 5pqo, 5pqp, 5pqq, 5pqr, 5pqs, 5pqt, 5pqu, 5pqv, 5pqw, 5pqx, 5pqy, 5pqz, 5pr0, 5pr1, 5pr2, 5pr3, 5pr4, 5pr5, 5pr6, 5pr7, 5pr8, 5pr9, 5pra, 5prb, 5prc, 5prd, 5pre, 5prf, 5prg, 5prh, 5pri, 5prj, 5prk, 5prl, 5prm, 5prn, 5pro, 5prp, 5prq, 5prr, 5prs, 5prt, 5pru, 5prv, 5prw, 5prx, 5pry, 5prz, 5ps0, 5ps1, 5ps2, 5ps3, 5ps4, 5ps5, 5ps6, 5ps7, 5ps8, 5ps9, 5psa, 5psb, 5psc, 5psd, 5pse, 5psf, 5psg, 5psh, 5psi, 5psj, 5psk, 5psl, 5psm, 5psn, 5pso, 5psp, 5psq, 5psr, 5pss, 5pst, 5psu, 5psv, 5psw, 5psx, 5psy, 5psz - hBRD1 residues 555-668 (mutant)

5n49 – hBRD1 bromodomain + inhibitor

5pny, 5pnz, 5po0, 5po1, 5po2, 5po3, 5po4, 5po5, 5po6, 5po7, 5po8, 5po9, 5poa, 5pob, 5poc, 5pod, 5poe, 5pof, 5pog, 5poh, 5poi, 5poj, 5pok, 5pol, 5pom, 5pon, 5poo, 5pop, 5poq, 5por, 5pos, 5pot, 5pou, 5pov, 5pow, 5pox, 5poy, 5poz, 5pp0, 5pp1, 5pp2, 5pp3, 5pp4, 5pp5, 5pp6, 5pp7, 5pp8, 5pp9, 5ppa, 5ppb, 5ppc, 5ppd, 5ppe, 5ppf, 5ppg, 5pph, 5ppi, 5ppj, 5ppk, 5ppl, 5ppm, 5ppn, 5ppo, 5ppp, 5ppq, 5ppr, 5pps, 5ppt, 5ppu, 5ppv, 5ppw, 5ppx, 5ppy, 5ppz – hBRD1 bromodomain (mutant) + inhibitor

5ame – hBRD1 bromodomain+PHD (mutant) + piperazine derivative

5amf – hBRD1 bromodomain+PHD (mutant) + indazole derivative

5fg6 – hBRD1 bromodomain+PHD + probe

3lyi – hBRD1 PWWP domain

7lh9 – hBRD1 PWWP domain + DNA

4z02 – hBRD1 PWWP domain + quinoline derivative

1x0j, 2dvv – hBRD2 bromodomain 1

5hel, 5hem, 5hen, 5hfq – hBRD2 bromodomain 1 (mutant)

2g4a – hBRD2 residues 1-116 - NMR

6cui – hBRD2 residues 621-750 - NMR

5ibn – hBRD2 bromodomain 2

4qeu, 5dfb – hBRD2 bromodomain 2 (mutant)

2dvq, 2dvr, 2dvs, 2e3k, 8sb6 – hBRD2 bromodomain 1 + histone H4 peptide

6u61, 6u8h, 6ulq – hBRD2 bromodomain 1 + peptide

3oni – hBRD2 residues 224-335 + inhibitor

3aqa, 2ydw, 2yek, 4a9e, 4a9f, 4a9h, 4a9i, 4a9j, 4a9m, 4a9n, 4a9o, 4alh, 4akn, 4alg, 4uyf, 4uyg, 4uyh, 6db0, 6ddi, 6jke, 6k05, 6ony, 6tq2, 7dpn, 7dpo, 7env, 7lah, 7lai, 7laj, 7lau, 7lay, 7npy, 7mpz, 7nq0, 7nq1, 7nq2,7nq3, 7nq5, 7nq7, 7nq8, 7nq9, 7nqi, 7nqj, 7oe4, 7oe5, 7oe6, 7oe8, 7oe9, 7oep, 7oer, 7oes, 7oet, 7ogy, 7usi – hBRD2 bromodomain 1 + inhibitor

7lak – hBRD2 bromodomain 1 + drug

7vrh, 7vrk, 7vro, 7vrz, 7vsf – hBRD2 bromodomain 1 + purine derivative

4mr5, 4mr6, 4j1p, 5ig6, 5ek9, 5dw1, 5xhk, 5xhe, 5u6v, 5n2l, 6mo7, 6mo8, 6mo9, 6moa, 6dbc, 6ddj, 6e6j, 6ffe, 6fff, 6ffg, 6k04, 6swo, 6swp, 6viy, 6wwb, 6z7f, 6z8p, 6zb0, 6zb1, 6zb2, 7enz, 7eo5, 7l6d, 7l72, 7l9g, 7l9j, 7l9k, 7lbt, 7npz, 7nq5, 7nq7, 7nq8, 7nq9, 7nqi, 7nqj, 7nqi, 7q5o, 7usg, 7wln, 7wmq, 7wmu, 7wn5, 7wna, 7wni, 8b5g, 8b5h, 8b5i, 8b5j, 8px8, 8wyg, 9fbx – hBRD2 bromodomain 2 + inhibitor

5o3i, 5o3h, 5o3g, 5o3f, 5o3e, 5o3d, 5o3c, 5o3b, 5o3a, 5o39, 5o38, 6ytm – hBRD2 bromodomain 2 (mutant) + inhibitor

7vri, 7vrm, 7vrq, 7vs0, 7vs1 – hBRD2 bromodomain 2 + purine derivative

6u71, 6ult, 7jx7, 8cv7, 8dnq – hBRD2 bromodomain 2 + peptide

5u5s – hBRD2 bromodomain 2 + STAT3 peptide - NMR

5bt5, 8px2– hBRD2 bromodomain 2 + probe

4qev, 4qew – hBRD2 bromodomain 2 (mutant) + probe

7uu0 – hBRD2 bromodomain 2 + ligand

5dfc, 5dfd – hBRD2 bromodomain 2 (mutant) + ligand

2nxb – hBRD3 bromodomain 1

2yw5 – hBRD3 bromodomain 1 - NMR

3s91, 3s92, 6qju, 7laz – hBRD3 bromodomain 1 + inhibitor

7r8r – hBRD3 bromodomain 1 + physachenolide

6u4a, 7rjk, 7rjl, 7rjm, 7rjn, 7to7, 7to9, 7toa – hBRD3 bromodomain 1 + peptide

2oo1 – hBRD3 bromodomain 2

2e7n – hBRD3 bromodomain 2 - NMR

5hfr – hBRD3 bromodomain 2 (mutant)

5hjc, 6ulp, 8cv5, 8b5a – hBRD3 bromodomain 2+ peptide

5a7c, 7l9l, 7lb4, 7s3p, 7ug5 – hBRD3 bromodomain 2 + inhibitor

7jmy – hBRD3 ET domain - NMR

6bgg, 6bgh, 7jq8, 7jyn, 7jyz – hBRD3 ET domain + peptide - NMR

2l5e – mBRD3 bromodomain 1 + GATA-1 C-terminal – mouse - NMR

2oss, 4j3i, 4lyi, 5hq7, 5hq6, 5hq5, 8ibq – hBRD4 bromodomain 1

2ouo – hBRD4 bromodomain 2

2i8n – hBRD4 bromodomain 2 - NMR

3jvj – mBRD4 bromodomain 1

2dww, 3jvl, 3jvm – mBRD4 bromodomain 2

2jns – mBRD4 ET domain - NMR

6dne – hBRD4 + inhibitor

8ov6 – hBRD4 + DCAF16 + DDB1 - Cryo EM

8g46 – hBRD4 + DCAF16 + DDB1 + DET1 - Cryo EM

2yel, 3p5o, 3svf, 3svg, 3u5j, 3u5k, 3u5l, 3zyu, 4a9l, 4bjx, 4bw1, 4bw2, 4bw3, 4bw4, 4c66, 4c67, 4cfk, 4cfl, 4cl9, 4clb, 4don, 4e96, 4f3i, 4gpj, 4hxk, 4hxl, 4hxm, 4hxn, 4hxo, 4hxp, 4hxr, 4hxs, 4hbv, 4hbw, 4hbx, 4hby, 4ioo, 4ioq, 4ior, 4j0r, 4j0s, 4lr6, 4lrg, 4lyw, 4lzs, 4men, 4meo, 4mep, 4meq, 4mr3, 4mr4, 4nqm, 4nr8, 4nuc, 4nue, 4nud, 4o70, 4o71, 4o72, 4o74, 4o75, 4o76, 4o77, 4o78, 4o7a, 4o7b, 4o7c, 4o7e, 4o7f, 4ogi, 4ogj, 4pce, 4pci, 4ps5, 4qr3, 4qr4, 4qr5, 4qzs, 4uix, 4uiy, 4uiz, 4uyd, 4wiv, 4x2i, 4xy9, 4xya, 4yh3, 4yh4, 4z1q, 4z1s, 4zc9, 4zw1, 5a5s, 5a85, 5acy, 5ad2, 5ad3, 5bt4, 5cfw, 5coi, 5cp5, 5cpe, 5cqt, 5crm, 5crz, 5cs8, 5ctl, 5cy9, 5d0c, 5d24, 5d25, 5d26, 5d3h, 5d3j, 5d3l, 5d3n, 5d3p, 5d3r, 5d3s, 5d3t, 5dlx, 5dlz, 5dw2, 5dx4, 5e0r, 5egu, 5ei4, 5eis, 5f5z, 5f60, 5f61, 5f62, 5f63, 5fbx, 5h21, 5hls, 5hm0, 5kdh, 5kj0, 5ku3, 5khm, 5i80, 5i88, 5lj1, 5lj2, 5lrq, 5luu, 5m39, 5m3a, 5mkz, 5mli, 5n2m, 5o97, 5ovb, 5ti7, 5u2f, 5u2e, 5u28, 5ula, 5v67, 5vom, 5uvw, 5vbo, 5vbp, 5vzs, 5w55, 5wa5, 5wma, 5wuu, 5xhy, 5xi2, 5xi3, 5xi4, 5y1y, 5y93, 5y94, 5y8c, 5y8w, 5y8y, 5y8z, 5yqx, 5z1r, 5z1s, 5z1t, 5z5t, 5z5u, 5z5v, 5z8g, 5z8r, 5z8z, 5z90, 5z9k, 6afr, 6ajv, 6ajw, 6ajx, 6ajy, 6cd4, 6cd5, 6cis, 6ciy, 6cj1, 6cj2, 6ckr, 6cks, 6czu, 6czv, 6djc, 6dl2, 6dmj, 6dml, 6e4a, 6fnx, 6fo5, 6fsy, 6ft3, 6ft4, 6hdq, 6i7x, 6i7y, 6in1, 6in2, 6ji3, 6ji4, 6ji5, 6jj3, 6jj5, 6jj6, 6jjb, 6kec, 6ked, 6kee, 6kef, 6keg, 6keh, 6kei, 6kej, 6kek, 6lg4, 6lg5, 6lg6, 6lg7, 6lg8, 6lg9, 6lih, 6lim, 6mau, 6mh1, 6mh7, 6p05, 6prt, 6ps9, 6psb, 6q3y, 6q3z, 6rwj, 6s25, 6s4b, 6s6k, 6sb8, 6se4, 6swn, 6swq, 6tpx, 6tpy, 6tpz, 6tq1, 6u0d, 6uvj, 6uvm, 6uwu, 6uwx, 6v0u, 6v1k, 6v1l, 6v1u, 6viw, 6vix, 6viz, 6vub, 6vuc, 6vuf, 6vuj, 6wgx, 6ww8, 6x7b, 6x7c, 6x7d, 6xv7, 6xvc, 6wvx, 6yin, 6yqn, 6yqo, 6yqp, 6z7g, 6z7l, 6z7m, 6zci, 6zed, 6zel, 6zf9, 7c2z, 7a9u, 7ajn, 7axr, 7b1t, 7c6p, 7dhs, 7ehw, 7ehy, 7eig, 7eik, 7eil, 7fh2, 7k6g, 7k6h, 7khl, 7kkw, 7jkw, 7jkx, 7jky, 7l9m, 7la9, 7lh8, 7m16, 7mce, 7mcf, 7mlq, 7mlr, 7mls, 7mr5, 7mr6, 7mr7, 7mr8, 7mr9, 7mra, 7mrb, 7rn2, 7o18, 7oeo, 7p6v, 7p6w, 7p6y, 7q3f, 7qdl, 7r5b, 7r9c, 7rek, 7rel, 7rem, 7rmd, 7rui, 7rxr, 7rxs, 7rxt, 7t3f, 7ugf, 7uty, 7uzn, 7v1u, 7v2j, 7w3d, 7wjs, 7wky, 7wl4, 7wwz, 7x6t, 6xuz, 7yl2, 7ymg, 7yq9, 8b96, 8b98, 8c11, 8ckf, 8dyr, 8e17, 8e3w, 8ead, 8fvk, 8gpz, 8gq0, 8k14, 8p9f, 8p9g, 8p9h, 8p9i, 8p9j, 8p9k, 8p9l, 8piq, 8pxa, 8pxm, 8pxn, 8q34, 8qal, 8qan, 8qap, 8qar, 8v9f, 8wiu, 8wqo, 8wxy, 8wy3, 8wy7, 8wyp, 9f1j, 9f1k, 9f1l, 9f1m, 9f1n, 9fwx, 9fxp – hBRD4 bromodomain 1 + inhibitor

5ti6, 5ti5, 5ti4, 5ti3, 5ti2, 5you, 5yov, 5wmd, 5wmg, 6g0d, 6g0e, 6g0f, 6g0g, 6g0h, 6hov – hBRD4 bromodomain 1 (mutant) + inhibitor

7z9w, 7z9y, 7za6, 7za7, 7za8, 7za9, 7zaa, 7zad, 7zae, 7zaj, 7zaq, 7zar, 7zat, 7ze6, 7ze7, 7zef, 7zen, 7zfn, 7zfo, 7zfs, 7zft, 7zfu, 7zfv, 7zfy, 7zfz, 7zg1, 7zg2 – hBRD4 bromodomain 1 + FragLite

5z9c – hBRD4 bromodomain 1 + inhibitor - NMR

4lys, 4lzr, 6ajz – hBRD4 bromodomain 1 + colchiceine

4qb3 – hBRD4 bromodomain 1 + olinone

4whw – hBRD4 bromodomain 1 + probe

5igk – hBRD4 bromodomain 1 + bromosporine

5hcl – hBRD4 bromodomain 1 + drug

6u6k, 6u72, 6u74, 6u8m, 6uls, 6ulv – hBRD4 bromodomain 1 + cyclic peptide

6bn7, 6bn8, 6bn9, 6bnb, 6boy – hBRD4 bromodomain 1 (mutant) + DNA damage-binding protein + cereblon

7khh, 7znt, 8bds, 8beb – hBRD4 bromodomain 1 + elongin-B + elongin-C + PVHL peptide + inhibitor

3uvw, 3uvy, 3uvx, 3uw9, 8b5b, 8b5c – hBRD4 bromodomain 1 + histone H4 peptide

7tuq, 7tv0 – hBRD4 bromodomain 1 + SARS peptide

4kv1, 5nng, 5nnf, 5nne, 5nng, 5nnf, 5nne, 6g0o, 6g0p, 7rjo, 7rjp, 7rjq, 7rjr, 7to8 – hBRD4 bromodomain 1 + peptide

8ewv – hBRD4 bromodomain 1 + elongin-B + elongin-C + PVHL peptide

6bnh – hBRD4 ET domain + JMJD6 peptide - NMR

3mxf – mBRD4 bromodomain 1 + inhibitor

3jvk, 3muk, 3mul, 5nnd, 5nnc – mBRD4 bromodomain 1 + histone H3.3 peptide

7usk – hBRD4 bromodomain 2

2yem, 4z93, 5u2c, 5jwm, 5uvz, 5uvy, 5uvx, 5uvv, 5uvu, 5uvt, 5uvs, 5uoo, 5uf0, 5uez, 5uey, 5uex, 5uew, 5uev, 5ueu, 5uet, 5ues, 5uer, 5ueq, 5uep, 5ueo, 6ffd, 6ffe, 6ffg, 6c7q, 6c7r, 6duv, 6i80, 6i81, 6zb3, 7c6p, 7jkz, 7ko0, 7ruh, 7ush, 7usj, 8idh, 8zmq, 9fby – hBRD4 bromodomain 2 + inhibitor

7aqt – hBRD4 bromodomain 2 + inhibitor - NMR

2lsp – hBRD4 bromodomain 2 + Nf-Kb peptide

4kv4 – hBRD4 bromodomain 2 + Rel peptide

2mjv – hBRD4 bromodomain 2 + Twist peptide

6mnl – hBRD4 bromodomain 2 + foxo3a peptide

6ko2 – hBRD4 bromodomain 2 + histone peptide

6u6l, 6u8g, 6u8i – hBRD4 bromodomain 2 + cyclic peptide

5t35, 6sis, 8bdt, 8bdx – hBRD4 bromodomain 2 + elongin-B + elongin-C + PVHL peptide

8rwz – hBRD4 bromodomain 2 + elongin-B + elongin-C + PVHL peptide + cullin + RBX1 – Cryo EM

8r5h – hBRD4 bromodomain 2 in cullin ring ligase – Cryo EM

6ppa – hBRD7 bromodomain

5mq1, 6v0q, 6v16, 6v17, 6v1e, 6v1f, 6v1h – hBRD7 bromodomain + inhibitor

7y84 – hBRD7 in nucleosome PBAF complex – Cryo EM

3hme, 6uzf – hBRD9 bromodomain

5ji8 – hBRD9 JUS-SPRY domain

5ign – hBRD9 bromodomain + L999

5igm – hBRD9 bromodomain + bromosporine

6v0x – hBRD9 bromodomain + sunitinib

4nqn, 4xy8, 4z6h, 4z6i, 5e9v, 5f2p, 5f25, 5f1l, 5f1h, 5eu1, 5mky, 6hm0, 6bqa, 6v0s, 6v14, 6v1b, 6y7h, 6y7j, 6y7k, 6y7i, 6y7l, 6yqr, 6yqs, 6yqw, 6yqz, 8a71, 8a7i, 8ahc – hBRD9 bromodomain + inhibitor

4yy4 – hBRD9 bromodomain + DMSO

4yy6, 4yyd, 4yyg, 4yyh, 4yyj, 4yyk, 4yyi – hBRD9 bromodomain + histone H4 peptide

4uit, 4uiu, 4uiv, 4uiw – hBRD9 JUS-SPRY domain + inhibitor

5i7y, 5i7x, 5i40 – hBRD9 JUS-SPRY domain + inhibitor

5twx – hBRD9 bromodomain residues 134-250 + heterobifunctional ligand