Caspase 3D structures

8wra – h-CASP - human

3e4c – hpro-CASP (mutant)

5fna – hCASP CARD domain – Cryo-EM

1sc1, 1sc4 - hCASP (mutant)

1sc3 - hCASP (mutant) + malonate

6bz9 - hCASP + polypeptide inhibitor

1ibc, 3d6f, 3d6h, 3d6m, 5mmv, 5mtk, 6f6r - hCASP (mutant) + polypeptide inhibitor

1bmq, 2hbq, 3ns7 - hCASP + inhibitor

1rwk, 1rwm, 1rwn, 1rwo, 1rwp, 1rwv, 1rww, 1rwx, 2fqq, 2h48, 2h4w, 2h4y, 2h51, 2h54, 2hbr, 2hby, 2hbz - hCASP (mutant) + inhibitor

1ice – hCASP + tetrapeptide aldehyde

6vie – hCASP + gasdermin

6kn0 – hCASP (mutant) + gasdermin

6pzp – hCASP + VX-765

7keu – hCASP CARD domain 2-86 + ASC CARD domain – Cryo-EM

8sv1 – hCASP subunits p10, p20 + interleukin-18 – Cryo-EM

2nn3 – pro-SfCASP (mutant) – Spodoptera frugiperda

1m72 – SfCASP + polypeptide inhibitor

2p2c – hCASP

3r7s - hCASP subunits P12, P18

1pyo, 3r5j, 3r6g, 3r6l, 3r7b, 3r7n, 3rjm - hCASP + polypeptide inhibitor

1qx3 - hCASP

2xyg, 2xyh, 2xyp, 4jje – hCASP subunits P12, P17 + inhibitor

2xzd, 2xzt, 2y0b - hCASP subunits P12, P17 + DARPIN-3.4

1cp3, 1pau, 2cdr, 2cnk, 2cnl, 2cnn, 2cno, 2h65, 3edq, 3edr, 3gjq, 3gjr, 3gjs, 3gjt, 3pcx, 3pd0, 3pd1, 4pry – hCASP + polypeptide inhibitor

4dcj, 4dco, 4dcp, 4eha, 4ehd, 4ehf, 4ehh, 4ehk, 4ehl, 4ehn, 4ps0, 4ps1, 6ckz, 6x8i, 7rn7, 7rn8, 7rn9, 7rna, 7rnb, 7rnc, 7rnd, 7rne, 7rnf, 7rng, 7seo, 7uso, 7usp, 7usq – hCASP subunits P12, P17 + polypeptide inhibitor

2cjx, 2cjy, 2dko, 4qtx, 4qty, 4qu0, 4qu5, 4qu8, 4qu9, 4qua, 4qub 4qud, 4qud, 4que, 4qug, 4quh, 4qui, 4quj, 4qul, 5i9b, 5i9t, 5iab, 5iae, 5iag, 5iaj, 5iak, 5ian, 5iar, 5ias, 5ibc, 5ibp, 5ibr, 6bdv, 6bfj, 6bfk, 6bfl, 6bfo, 6bg0, 6bg1, 6bg4, 6bgk, 6bgq, 6bgr, 6bgs, 6bh9, 6bha - hCASP (mutant) + polypeptide inhibitor

1gfw, 1nme, 1nmq, 1nms, 1re1, 1rhj, 1rhk, 1rhm, 1rhq, 1rhr, 1rhu, 3deh, 3dei, 3dej, 3dek, 3h0e, 3kjf – hCASP + inhibitor

2c1e, 2c2k, 2c2m, 2c2o, 2c2z, 2h5i, 2h5j, 2j30, 2j31, 2j32, 2j33, 3itn, 4jr0 – hpro-CASP + polypeptide inhibitor

4jqy, 4jqz - hpro-CASP (mutant)

1i3o - hCASP (mutant) + XIAP-BIR2

7wr6 - hCASP (mutant) + ADPR-glycohydrolase

7xn4 - hCASP + CopC + calmodulin + nicotinamide – Cryo EM

7xn5, 7xn6, 8e2j - hCASP + CopC + calmodulin + ADPR + nicotinamide – Cryo EM

6wi4 – CASP + inhibitor – Porites asteroides

6nry – hCASP

7wr0 – hCASP (mutant)

6kmz – hCASP (mutant) + gasdermin

7wr1 – hCASP + Ospc3 C-terminal

7wr4, 7wr5 – hCASP (mutant) + calmodulin + Ospc3

8j6k, 8spb – hCASP subunits p10, p20 + interleukin-18 – Cryo-EM

6kmt, 6kmu, 6kn1 – mCASP (mutant) - mouse

6kmv – mCASP (mutant) + gasdermin

2wdp, 3k7e, 3p45 – hCASP

3nkf, 3nr2, 3s8e, 3v6l, 3v6m, 4iyr, 6deu, 6dev – hCASP (mutant)

3od5, 3p4u, 3qnw, 3s70 – hCASP + polypeptide inhibitor

4ejf – hCASP subunit P11 + P18 + polypeptide

4fxo - hCASP subunit P11 + P18 + Zn

4hva - hCASP subunit P11 + P18 + VEID inhibitor

4n5d, 8eg5, 8eg6 - hCASP subunit P11 + P18 + inhibitor

6ppm - hCASP subunit P11 + P18 + polypeptide inhibitor

4n6g, 4n7j, 4n7m, 4nbk, 4nbl, 4nbn - hCASP subunit P11 + P18 (mutant) + inhibitor

3rk5, 4fdl - hCASP

5k20 – hCASP large + small (mutant) subunits

3ibf – hCASP large subunit

3r5k, 4hq0 - hCASP (mutant)

1gqf, 1k86 – hCASP catalytic domain

1k88 – hpro-CASP (mutant)

2ql5, 2ql7, 2ql9, 2qlb, 2qlf, 2qlj, 3edr, 3ibc - hCASP large subunit + polypeptide inhibitor

1f1j, 4hqr - hCASP + polypeptide inhibitor

6x8j, 6x8k, 6x8l - hCASP subunits p11, p20 + polypeptide inhibitor

8dgz - hCASP + peptide + inhibitor

7wzs – hCASP + calmodulin + CopC

3h1p, 4jr1, 4jr2 - hCASP catalytic domain (mutant) + polypeptide inhibitor

1shj, 1shl - hCASP catalytic domain (mutant) + inhibitor

4fea, 5v6u, 5v6z, 8dj3 - hCASP catalytic domain + inhibitor

1i51, 1kmc - hCASP (mutant) + XIAP-BIR2

1i4o - hCASP P20 subunit + XIAP

4jb8, 4lsz - hCASP large+small subunits + DARPIN

4zvo, 4zvp, 4zvq, 4zvr, 4zvs, 4zvt, 4zvu, 5ic6, 5ic4, 6cl0, 6cl1, 6cl2 - hCASP large+small subunits + peptide inhibitor

5l08 – hCASP – Cryo-EM

6xkj – hCASP CARD domain 451-537 – Cryo-EM

4zbw, 7lvj, 7lvm - hCASP death effector domain

5h31, 5h33 - hCASP death effector domain (mutant)

6agw - hCASP pro domain 1-180

3kjn, 3kjq – hCASP subunit P18 + inhibitor

1f9e, 1qdu, 1qtn - hCASP subunit α,β + polypeptide inhibitor

1qtn, 4jj7, 4jj8, 4prz - hCASP P18, P11 + polypeptide inhibitor

3h11 - hCASP (mutant) + polypeptide inhibitor

2y1l - hCASP subunits P18 P10

6x8h - hCASP P18, P10 + polypeptide inhibitor

8ym4, 8ym5, 8ym6, 8ynk, 8ynm, 8ynn - hCASP subunit P10 + apoptosis regulator – Cryo EM

8ybx, 8yd7, 8yd8, 8yni - hCASP (mutant) + apoptosis regulator + FADD – Cryo EM

6px9 - hpro-CASP catalytic domain 276-538 + inhibitor

2k7z – hpro-CASP catalytic domain (mutant) – NMR

1i4e, 2fun – CASP + P35 – Autographa californica

2ar9 – hCASP (mutant)

1jxq - hCASP + polypeptide inhibitor

3v3k – hCASP + effector protein

5juy, 5wvc, 5wve – hCASP CARD domain + APAF-1

1nw9 – hCASP catalytic domain + XIAP-BIR3

3ygs, 4rhw – hpro-CASP + APAF-1 CARD

6ns7 – mCASP 60-243

6kxg – mCASP CARD domain 1-463

2fp3 – DmCASP Dronc residues 136-450 – Drosophila melanogaster

8ynl - DmCASP DronC residues 10-111 + Dark

3sir - DmCASP drICE residues 78-332

3sip – DmCASP drICE residues 78-230 + apoptosis inhibitor

4af8, 4afp, 4afr, 4afv – MCASP (mutant) – Trypanosom brucei

4f6o – yMCASP 1 – yeast

4f6p – yMCASP 1 (mutant)