Ceruloplasmin

Function

Ceruloplasmin (CP) is a ferroxidase which is the major copper-carrying protein in the blood. It functions in iron metabolism.^[1]

Relevance

CP testing is used in diagnosis of the rare inherited disorder - Wilson disease.

Disease

CP mutation causes the autosomal recessive disorder - Aceruloplasminemia which results in accumulation of iron in the brain.

Structural highlights

and

in human ceruloplasmin (PDB entry 1kcw).