Clarithromycin

From Proteopedia

Clarithromycin, sold under the brand name Biaxin among others, is an antibiotic used to treat various bacterial infections. This includes strep throat, pneumonia, skin infections, H. pylori infection, and Lyme disease, among others. Clarithromycin can be taken by mouth as a pill or liquid.^[1] See also Clarithromycin.

Clarithromycin prevents bacteria from multiplying by acting as a protein synthesis inhibitor. It binds to 23S rRNA, a component of the 50S subunit of the bacterial ribosome, thus inhibiting the translation of peptides.

Clarithromycin bound to 23S RRNA (1j5a).

loadScript /wiki/extensions/jsmol/j2s/core/package.js

loadScript /wiki/extensions/jsmol/j2s/core/corejmol.z.js

loadScript /wiki/extensions/jsmol/j2s/J/translation/PO.js

loadScript /wiki/extensions/jsmol/j2s/core/corescript.z.js

JSmol exec jmolApplet1 start applet null

Jmol JavaScript applet jmolApplet1__391237599094629__ initializing

Jmol getValue debug null

Jmol getValue logLevel null

Jmol getValue allowjavascript null

AppletRegistry.checkIn(jmolApplet1__391237599094629__)

vwrOptions:

{ "name":"jmolApplet1","applet":true,"documentBase":"https://proteopedia.org/wiki/index.php/Clarithromycin","platform":"J.awtjs2d.Platform","fullName":"jmolApplet1__391237599094629__","codePath":"https:/wiki/extensions/jsmol/j2s/","display":"jmolApplet1_canvas2d","loadStructCallback":"manageLoadStructCallback","signedApplet":"true","appletReadyCallback":"Jmol._readyCallback","statusListener":"[J.appletjs.Jmol object]","syncId":"391237599094629","messageCallback":"msgCb","bgcolor":"white" }

setting document base to "https://proteopedia.org/wiki/index.php/Clarithromycin"

Jmol Version: 14.31.8 2020-09-26 10:04

java.vendor: Java2Script (HTML5)

java.version: 2019-06-08 00:17:46 (JSmol/j2s)

os.name: Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)

Access: ALL

memory: 0.0/0.0

processors available: 1

useCommandThread: false

appletId:jmolApplet1 (signed)

Jmol getValue emulate null

defaults = "Jmol"

Jmol getValue boxbgcolor null

Jmol getValue bgcolor white

backgroundColor = "white"

Jmol getValue ANIMFRAMECallback null

Jmol getValue APPLETREADYCallback Jmol._readyCallback

APPLETREADYCallback = "Jmol._readyCallback"

StatusManager callback set for APPLETREADYCallback f=Jmol._readyCallback cb=APPLETREADY

Jmol getValue ATOMMOVEDCallback null

Jmol getValue AUDIOCallback null

Jmol getValue CLICKCallback null

Jmol getValue DRAGDROPCallback null

Jmol getValue ECHOCallback null

Jmol getValue ERRORCallback null

Jmol getValue EVALCallback null

Jmol getValue HOVERCallback null

Jmol getValue IMAGECallback null

Jmol getValue LOADSTRUCTCallback manageLoadStructCallback

LOADSTRUCTCallback = "manageLoadStructCallback"

StatusManager callback set for LOADSTRUCTCallback f=manageLoadStructCallback cb=LOADSTRUCT

Jmol getValue MEASURECallback null

Jmol getValue MESSAGECallback msgCb

MESSAGECallback = "msgCb"

StatusManager callback set for MESSAGECallback f=msgCb cb=MESSAGE

Jmol getValue MINIMIZATIONCallback null

Jmol getValue SERVICECallback null

Jmol getValue PICKCallback null

Jmol getValue RESIZECallback null

Jmol getValue SCRIPTCallback null

Jmol getValue SYNCCallback null

Jmol getValue STRUCTUREMODIFIEDCallback null

Jmol getValue doTranslate null

language=en_US

Jmol getValue doTranslate null

Note -- Presence of message callback disables disable translation; to enable message translation use jmolSetTranslation(true) prior to jmolApplet()

Note -- language translation disabled

Jmol getValue popupMenu null

Jmol getValue script null

Jmol getValue loadInline null

Jmol getValue load null

Jmol applet jmolApplet1__391237599094629__ ready

script 1 started

pdbGetHeader = true

FileManager opening url https://proteopedia.org/wiki/extensions/Proteopedia/spt/functions.spt?1733933141

loadScript /wiki/extensions/jsmol/j2s/core/coretext.z.js

Loading, please wait ...

platformSpeed = 8

FileManager opening url https://proteopedia.org/wiki/scripts/10/1007563/Cv/1.spt

FileManager.getAtomSetCollectionFromFile(https://proteopedia.org/wiki/images/9/9c/10342604.mol)

FileManager opening url https://proteopedia.org/wiki/images/9/9c/10342604.mol

The Resolver thinks Mol

Marvin 01010805553D

stdinchi:"InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33+,35+,36-,37-,38-/m1/s1"

stdinchikey:"AGOYDEPGAOXOCK-JWSJYYAVSA-N"

auxinfo:"1/0/N:45,38,48,40,27,47,26,24,37,43,50,52,23,36,44,32,12,3,13,31,15,9,21,6,33,18,2,14,34,8,16,5,10,20,29,4,11,17,49,39,51,41,25,46,42,22,35,30,1,19,7,28/E:(11,12)/it:im/rA:52cOCCCCCOCCCCCCCCCCCOCCOCCOCCOCOCCCCOCCCOCOOCCCOCCNCOC/rB:s1;s2;s3;s4;s1s5;s2;s7;s8;s9;s10;s11;s12;s13;s14;s15;s16;s17;s18;s19;s8s20;s4;s22;s4;s5;s6;s9;s10;s28;s29;s30;s31;s32;s29s33;s11;s35;s11;s13;d14;s15;s16;s17;s17;s18;s44;d20;s21;s31;s33;s49;s34;s49;/rC:-3.927,.871,-2.0372;-2.5632,.9252,-1.5504;-1.8197,2.0884,-2.2707;-2.5648,3.4693,-2.2313;-4.1169,3.3301,-2.4677;-4.8057,2.0238,-1.9648;-2.0186,-.38,-1.7759;-.7071,-.7357,-1.2737;-.6375,-1.0909,.244;-.1535,-.0266,1.2822;1.3936,.1802,1.5243;2.3725,-.9438,1.021;2.8128,-2.2833,1.6947;3.8518,-3.0026,.9346;3.9515,-4.4584,.8002;3.3238,-5.1105,-.4617;3.7342,-4.6802,-1.9052;3.3743,-3.2092,-2.3293;2.0591,-2.9109,-2.2036;1.4068,-1.8356,-2.2115;-.0427,-1.8981,-2.0958;-2.1232,4.4008,-3.2641;-.7638,4.8019,-3.5542;-2.3948,4.1308,-.8375;-4.4673,3.3626,-3.8494;-5.4997,2.186,-.6049;-1.8491,-1.8505,.8205;-.8895,1.2228,1.2562;-1.9382,1.3434,2.2401;-2.8626,2.3985,1.8595;-3.968,2.6983,2.7595;-3.5489,2.8252,4.2541;-1.9941,2.7972,4.4791;-1.4122,1.5611,3.7006;1.8991,1.506,1.2269;1.9969,2.0537,-.1011;1.5816,.3155,3.053;1.5583,-3.0616,2.167;4.7577,-2.3416,.4318;5.289,-5.1147,1.2003;1.9103,-5.0888,-.2576;5.1466,-4.8649,-1.9778;3.2187,-5.793,-2.8488;3.9279,-2.7492,-3.7093;5.2948,-2.0683,-3.5868;1.9556,-.7442,-2.3525;-.595,-2.1616,-3.5186;-4.6317,4.0214,2.3636;-1.3574,4.1257,4.1706;-1.6299,5.1755,5.1699;-1.6487,.3579,4.4203;.114,4.2316,4.1674;"

formula:"C38 H69 N O13"

mw:"747.9534"

smiles:"O1[C@@H](C)[C@H](O)[C@@](OC)(C)C[C@@H]1O[C@@H]1[C@@H](C)C(=O)O[C@H](CC)[C@](O)(C)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@H]1C"

csid:"10342604"

Time for openFile(https://proteopedia.org/wiki/images/9/9c/10342604.mol): 795 ms

reading 52 atoms

ModelSet: haveSymmetry:false haveUnitcells:false haveFractionalCoord:false

1 model in this collection. Use getProperty "modelInfo" or getProperty "auxiliaryInfo" to inspect them.

Default Van der Waals type for model set to Babel

52 atoms created

ModelSet: not autobonding; use forceAutobond=true to force automatic bond creation

manageLoadStructCallback failed TypeError: Cannot read properties of undefined (reading 'replace')

Time for creating model: 9 ms

loadScript /wiki/extensions/jsmol/j2s/core/corescriptcmd.z.js

RasMol pseudo-hbond calculation

0 hydrogen bonds

loadScript /wiki/extensions/jsmol/j2s/J/thread/SpinThread.js

Script completed

Jmol script terminated

Clarithromycin

Drag the structure with the mouse to rotate

Export Animated Image

References

↑ "Clarithromycin". The American Society of Health-System Pharmacists. Archived from the original on September 3, 2015. Retrieved September 4, 2015.

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

Retrieved from "http://proteopedia.org/wiki/index.php/Clarithromycin"

Clarithromycin

From Proteopedia

References

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox