Function
DnaJ homolog subfamily A member 1 (DnaJA1) is a co-chaperone for HSPA8/Hsc70. DnaJA1 stimulates ATP synthesis and has a role in protein transport into mitochondria[1].
DnaJ homolog subfamily B member 1 (DnaJB1) interacts with HSP70. DnaJB1 stimulates ATP synthesis and the folding of unfolded proteins mediated by HSPA1A [2].
Disease
DnaJA1 is down-regulated 5-fold in pancreatic cancer and is targeted as a biomarker for it.
Relevance
DnaA1 promotes apoptosis in response to cell stress mediated by exposure to UV[3].
Structural highlights
includes various hydrogen bonds, salt bridges and hydrophobic interactions. The octapeptide assumes an extended conformation and forms an antiparallel β sheet with β2 domain I[4].
3D structures of DnaJ homolog
DnaJ homolog 3D structures