Elongation factor 3D structures

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3D structures of elongation factor

Updated on 16-February-2023

EF-Tu

1ls2 – yEF + Phe-tRNA – yeast – Cryo EM

1efm, 1efc, 1dg1, 2fx3, 1etu, 5mi3 – EcEF – Escherichia coli

5mi8, 5mi9 – EcEF (mutant)

1qzd – EcEF – Cryo EM

3u2q – EcEF + drug

1mj1 – EcEF + Phe-tRNA + S12 + S13 + L11 – Cryo EM

3ep2 - EcEF + tRNA + S12 + L11 + 16SRRNA + 23SRRNA – Cryo EM

1ttt, 1ob5 – TaEF + Phe-tRNA + GDPNP - Thermus aquaticus

1b23 - TaEF + Cys-tRNA

3wxm – ApEF + plethora protein – Aeropyrum pernix

6ji2 - ApEF + plethora protein + AP2

4h9g, 4lbv, 4lbw, 4lby, 4lbz, 4lc0 – TtEF – Thermus thermophilus

4j0q – PpEF – Pseudomonas putida

5w75 – EF – Thermotoga neapolitana

5tbf – EF domain 2-3– Vibrio cholerae"

5w76, 6htw, 6i8r, 7bbn – EF – synthetic

EF-Tu complex with antibiotics

1ob2 - yEF + Phe-tRNA + antibiotic

4v8q - TtEF + antibiotic in 30S ribosome

1ha3 - TtEF + antibiotic + GDP

2c77, 2c78 - TtEF + antibiotic + GTP analog

4v68 – TtEF + antibiotic in 70S ribosome – Cryo EM

2bvn - EcEF + GDP
NP + antibiotic

1d8t, 2hcj, 2hdn, 3u6b, 3u6k, 4g5g, 5jbq – EcEF + antibiotic

7st7 – EcEF + antibiotic in 70S ribosome – Cryo EM

EF-Tu complex with nucleotide

1d2e – bEF + GDP – bovine

6eze – EcEF + GDP derivative

5opd – EcEF + GTP

1exm – TtEF + GTP analog

1eft – TaEF + GNP – Thermus aquaticus

1tui – TaEF + GDP

1jny, 1skq – SsEF + GDP – Sulfolobus solfataricus

3wya – PhEF + GDP - Pyrococcus horikoshii

6mij – AbEF + GDP – Acinetobacter baumannii

6gfu – EF + GDP – synthetic

7vok – MtEF + GDP – Mycobacterium tuberculosis

EF-Tu complex with protein

3vmf – ApEF + translation termination factor

3wy9 – PhEF + L12

4p3y – EcEF + thiol:disulfide interchange protein

5i4r, 5i4q, 7vmc – EcEF + CDIA + CDII

4zv4 – PaEF + TSE6 - Pseudomonas aeruginosa

4iw3 – PpEF + prolyl hydroxylase

5v7y – EF + prolyl hydroxylase – Bacillus anthracis

EF-Tu with EF-Ts

1xb2 – bEF + EF-Ts - bovine

1f60 – yEF + EF-Ts C terminal

1g7c - yEF + EF-Ts C terminal + GDPNP

1ije, 1ijf - yEF + EF-Ts C terminal + GDP

2b7b - yEF + EF-Ts C terminal (mutant) + GDP

2b7c - yEF + EF-Ts C terminal (mutant)

1efu, 3agp, 3agq, 4pc1 – EcEF + EcEF-Ts

3avt, 3avu , 3avv, 3avw, 3avx, 3avy, 3vnu , 3vnv, 4fwt – EcEF + EcEF-Ts + RNA

3mmp – EcEF + EcEF-Ts + RNA replicase beta chain

4q7j – EcEF + EcEF-Ts + Q beta replicase + S1

4r71 – EcEF + EcEF-Ts + RNA polymerase β chain + S1

4pc7 – EcEF + EcEF-Ts + antibiotic + GNP

4pc2, 4pc3, 4pc6 – EcEF + EcEF-Ts + GDP derivative

1aip - TtEF + TtEF-Ts - Thermus thermophilus

7vmx – MtEF + MtEF-Ts

EF-Tu in the ribosome

7a5g, 7o9k – hEF in 80S mitoribosome + GMPPCP – Cryo EM

3eq3, 3eq4, 5afi – EcEF in 80S ribosome – Cryo EM

6wd2, 6wd3, 6wd4, 6wd5, 6wd6, 6wd7, 6wd8, 6wd9, 6wda – EcEF in 80S ribosome + GDP – Cryo EM

4v6l, 4v6k, 4v69 - EcEF in 30S ribosome – Cryo EM

5lzc, 5uyk, 5uyl, 5uym, 5uyn, 5uyp, 5uyq, 5wdt, 5we4, 5we6, 5wf0, 5wfk, 5wfs - EcEF in 70S ribosome – Cryo EM

5imq, 5imr, 6zmo - EcEF in 70S ribosome + Nsp1– Cryo EM

1zc8, 3dwu – TtEF in 70S ribosome – Cryo EM

7paj, 7pak, 7pao, 7paq, 7par, 7pha, 7pi4, 7pi9, 7pib, 7pip, 7pis, 7pit – MpEF in 70S ribosome – Mycoplasma pneumoniae - Cryo EM

4v5g, 4v5l, 4v5p, 4v5q, 4v5r, 4v5s - TtEF in 70S ribosome

EF-SII

1tfi – hEF – human – NMR

3ndq - hEF domain II

1wjt – mEF N terminal – mouse – NMR

1enw – yEF domain II – NMR

1eo0 - yEF domain I – NMR

1pqv, 1y1v – yEF + RNA polymerase II

1y1y, 3gtm – yEF + RNA polymerase II + RNA

2xex – SaEF – Staphylococcus aureus

2m1h – EF PWWP domain – Trypanosoma brucei – NMR

EF-ELL2

2e5n – hEF N2 domain - NMR

5jw9 – hEF + AFF4 peptide

EF-G

1efg, 1elo, 1ktv, 1wdt, 2dy1 – TtEF

4m1k, 4myt, 4myu – TtEF (mutant)

1pn6, 3izp, 5ot7 – TtEF – Cryo EM

1fnm, 2bm0, 2bm1 – TtEF (mutant)

2bcw – TtEF + L11 + L7/L12

2bv3 - TtEF (mutant) + GTP analog

2j7k - TtEF (mutant) + GDP analog

1dar, 2efg – TtEF + GDP

1jqm, 1jqs – EcEF + L11 – Cryo EM

4fn5 – PaEF

5tv2 – EF – Vibrio vulnificus

5ty0 – EF N terminal – Legionella pneumophila

5vh6 – EF N terminal – Bacillus subtilis

6b8d – EF N terminal – Haemophilus influenzae

6not – EF – Rickettsia prowazekii

6bk7 – EF N terminal – Enterococcus faecalis

6n0i – PpEF 2

7cdw – MtEF

2xex – SaEF

3zz0, 3zzt, 3zzu – SaEF (mutant)

2mzw – SaEF domains III-V + FAR1

EF-G in the ribosome

4v6x, 6vlz, 6z6m, 6z6n, 7a5k, 7w59, 7w5a – hEF in 80S ribosome – Cryo EM

6vmi – hEF in 80S mitoribosome – Cryo EM

7l20 – hEF in 39S mitoribosome – Cryo EM

7nsh – pEF in 39S ribosome – pig - Cryo EM

6ydp, 6ydw – pEF in 55S ribosome – Cryo EM

7oyd – rEF in 80S ribosome – Cryo EM

4v6w – DmEF in 80S ribosome – Cryo EM

4v8u, 4v5m, 4v5n, 4w29, 4wpo, 4wqf, 4wqu, 4wqy – TtEF in 70S ribosome

2om7, 4v5f, 4v7c – TtEF in 70S ribosome – Cryo EM

4v9h, 4v9j, 4v9k, 4v9l, 4v9m, 4v90 – TtEF in 30S ribosome

4v9o, 4v9p – EcEF in 30S ribosome

4v9d – EcEF in 30S ribosome + antibiotics – Cryo-EM

1zn0, 2rdo, 3j0e, 3ja1, 4v6t, 4v9b, 7k51, 7k52, 7k54 – EcEF in 30S ribosome – Cryo-EM

3j9z, 4v7b, 4v7d, 7k55, 7n2c, 7n2v, 7pjv, 7pjw, 7pjx, 7pjy, 7pjz, 7ssd, 7ssl, 7ssp, 7ug7 – EcEF in 70S ribosome – Cryo-EM

7otc – EcEF in 70S ribosome + antibiotics – Cryo-EM

EF-GreA/GreB

2pn0 – EF – Nitrosomonas europaea

2p4v – EcEF-GreB

1grj – EcEF-GreA

6ri7, 6rin – EcEF-GreB + transcriptase + DNA + RNA – Cryo EM

EF-NusA

1wcl, 1wcn – EcEF C terminal – NMR

2kwp - EcEF N terminal – NMR

2jzb – EcEF + RNA polymerase subunit α - NMR

EF-P

1ueb – TtEF

4v6a – TtEF in 70S ribosome

3oyy – PaEF

6j7m – PaEF + EARP

3tre – EF – Coxiella burnetii

3a5z – EcEF + lysyl-tRNA synthetase

6enj, 6enu – EcEF – Cryo EM

1yby – EF – Clostridium thermocellum

5j3b – AbEF

6rji – SaEF

6rk3 – SaEF - NMR

6s8z – EF – Corynebacterium glutamicum

5wxk – EF + EARP – Neisseria meningitidis

EF-Ts

2uz8 – hEF (mutant)

1b64 – hEF guanine exchange factor domain – NMR

2cp9 – hEF UBA domain – NMR

1gh8 – EF – Methanobacterium thermoautotrophicum – NMR

2yy3 – PhEF

1tfe – TtEF

EF-1

8b6z – hEF alpha in 80S ribosome – Cryo EM

5dqs – hEF β+γ

5jpo – hEF γ+δ

1pbu – hEF γ C terminal (mutant) - NMR

2mvm, 2mvn – hEF δ-1 CAR domain – NMR

2n51 – hEF δ-1 C terminal – NMR

5bmu – hEF ε-1 + Glu tRNA ligase

5y6l – hEF ε-1 (mutant) + MetRS + AspRS + Glu/Pro tRNA ligase + P38

5lzs – rEF α-1 in 80S ribosome+ drug – rabbit

4c0s, 6ra9 – rEF α-2

5o8w – yEF α+β

1nhy – yEF γ N terminal

7csl – PhEF α+β

EF-2

4v4b - hEF in 40S ribosome – Cryo EM

3j7p - pEF in 80S ribosome – Cryo EM

4cxg, 4cxh - rEF in 40S ribosome – Cryo EM

7ls1, 7ls2 - mEF in 80S ribosome – Cryo EM

4v6w - DmEF in 40S ribosome – Cryo EM

7osm - yEF in 80S ribosome

5jup, 5jus, 5jut, 5juu, 6gq1, 7osa - yEF in 80S ribosome – Cryo EM

1n0v – yEF

1u2r – yEF + GDP

1n0u, 2e1r, 2npf – yEF + antifungal drug

1zm2, 1zm3, 1zm4, 1zm9, 3b78, 3b82, 3b8h, 2zit – yEF + exotoxin

2p8w, 2p8x, 3dny, 6gqb, 6gqv - yEF in 80S ribosome – Cryo EM

2p8y, 2p8z, 5juo- yEF+ antifungal drug in 80S ribosome – Cryo EM

5h7j - PhEF

5h7l - PhEF + L12

5h7k - PhEF + GDP

6u45 – MnEF + GMPPCP – Methanoperedens nitroreducens

6u43, 6u44 – MnEF (mutant) + GMPPCP

6q2d - EF + DPH2 – Methanobrevibacter smithii

EF-3

2ix3 – yEF

2iwh – yEF + ADPNP

2iw3 – yEF + ADP

2ix8, 7b7d – yEF in 80S ribosome – Cryo EM

EF-4 (lepA)

2ywh, 2ywe, 2ywf, 2ywg - AalepA + nucleotide - Aquifex aeolicus

3cb4 - EclepA

3deg, 3jcd, 3jce - EclepA in 70S ribosome + GMPPNP – Cryo EM

5j8b - TtlepA in 70S ribosome + GDPCP

4w2e - TtlepA in 70S ribosome

EF-SelB

5izk, 5izl, 5izm – hEF + GDP derivative

1lva – MtEF C terminal – Moorella thermoacetica

2v9v – MtEF winged helix domain

1wsu, 2uwm – MtEF + RNA

2ply – MtEF (mutant) + RNA

4zu9 - AaEF

4aca – MmEF – Methanococcus maripaludis

4acb – MmEF + GTP analog

4ac9 – MmEF + GDP

2pjp – EcEF + RNA

EF-Spt4 + EF-Spt5

3h7h – hEF-Spt4 residues 2-117 + hEF-Spt5 residues 176-273

6gmh, 6gml – hEF-Spt4 + EF-Spt5 + EF-Spt6 in transcription complex – Cryo EM

5oik – bEF-Spt4 + EF-Spt5 + RNA polymerase II

7nkx, 7nky – yEF-Spt4 + EF-Spt5 + EF-Spt16 in RNA polymerase II elongation complex - CryoEM

2exu – yEF-Spt4 residues 1-99 + EF-Spt5 residues 285-375

4zn3, 4zn1 – EF-Spt4 + EF-Spt5 – Methanocaldococcus jannaschii

5xon, 5xog, 6ir9, 6j4w, 6j4x, 6j4y, 6j4z, 6j50, 6j51 – EF-Spt4 + EF-Spt5 + EF-Tfiis in RNA polymerase II elongation complex - Komagataella phaffii - Cryo EM

EF-Spt5

2e6z – hEF KOW2 motif residues 420-471 – NMR

2do3 – hEF KOW3 motif residues 462-523 – NMR

6eqy – hEF KOW4 motif residues 522-647 – NMR

2e70 – hEF KOW5 motif residues 694-757 – NMR

6er0 – hEF KOW6 motif residues 961-1087 – NMR

2do3, 2e6z, 2e70 – hEF KOW motif residues 694-757 – NMR

5ohq – hEF KOW6-KOW7 domain residues 939-1087

5oho – hEF KOWX-KOW4 domain residues 536-646

7okx, 7ol0 – pEF-Spt5 in RNA polymerase II transcription complex – Cryo EM

4ytl – yEF KOW2-KOW3 domain residues 534-632

4ytk – yEF KOW1-linker domain residues 382-511

2exu – yEF

EF-Spt6

4z2n – hEF middle domain residues 644-930

4z2m – hEF middle domain + histone H3.1 + histone H4

6gme – hEF SH2 domain residues 1317-1334

7oop, 7opc, 7opd – hEF-Spt6 in RNA polymerase II transcription complex – Cryo EM

6ted, 7unc, 7und – pEF in RNA polymerase II transcription complex - CryoEM

3psf, 3psi – yEF core domain residues 235-1259

3psj, 3psk – yEF SH2 domain residues 1247-1451

5vkl, 5vko – yEF SH2 domain + RPB1 peptide

2l3t - yEF SH2 domain - NMR

3oak – yEF + transcription factor IWS1

3gxw, 3gxx, 3pjp – EF SH2 domain – Candida glabrata

6qtc – CgEF SH2 domain + Tyr phosphorylated CTD – NMR

2xp1 – EF SH2 domain – Antonospora locustae

EF-Spt16

5umu, 5umt, 5xm2 – hEF

5e5b - hEF N-terminal

EF-M2-1

5nkx, 5noh – EF core domain – human respiratory cyncytial virus

EF-TEFM mitochondrial

5ol9 - hEF N-terminal

5ol8 - hEF C-terminal

5ola - hEF + RNA polymerase + RNA + DNA

EF-CA150

2dod, 2doe, 2dof, 2e71, 2kiq, 2kis – hEF FF domain – NMR

3hfh – hEF FF domain

2ysi– mEF WW domain - NMR

Elongin A

4hfx – hEloA F-box domain

6zuz – hEloA N-terminal

Elongin C

5zb2 – yEloC + Rad7

1hv2 - yEloC + von-Hippel Lindau disease tumor suppressor - NMR

Elongin BC complex

1lqb, 1lm8 – hEloBC + VHL + hypoxia inducible factor 1 α

6i7q, 6i7r – hEloBC + VHL + hypoxia inducible factor 2 α

7q2j, 8bb2, 8bb3, 8bb4, 8bb5 – hEloBC + VHL + WD repeat-containing protein 5

7jto, 7jtp – hEloBC + VHL + WD repeat-containing protein 5 + inhibitor

7znt – hEloBC + VHL + bromodomain-containing protein 4

3zrc, 3ztc, 3ztd, 3zun, 4awj, 4b95, 4b9k, 4bks, 4bkt, 4w9l, 4w9k, 4w9j, 4w9i, 4w9h, 4w9g, 4w9f, 4w9e, 4w9d, 4w9c, 5nw2, 5nw1, 5nw0, 5nvz, 5nvy, 5nvx, 5nvw, 5nvv, 6fmi, 6fmj, 6fmk, 6gfy, 8c13 - hEloBC + VHL + inhibitor

5t35, 6sis - hEloBC + VHL + BRD4

7khh - hEloBC + VHL + BRD4 + inhibitor

7s4e, 7z6l, 7z76, 7z77 - hEloBC + VHL + SMARCA2 + inhibitor<br /

4wqo - hEloBC + VHL + cullin-2

6hr2, 6hay, 6hax - hEloBC + VHL + transcription activator

4ajy - hEloBC + hypoxia inducible factor peptide

6gmr, 6gfx, 6bvb - hEloBC + VHL + hypoxia inducible factor peptide

5n4w - hEloBC + von-Hippel Lindau disease tumor suppressor + cullin-2 + RBX1

4n9f - hEloBC + VIF+ cullin-5 + CBF

2ma9 - hEloBC + VIF - NMR

3zrf, 5lli, 6gmx, 6gmq, 6gmn, 6gfz - hEloBC + VHL

6zhc - hEloBC + VHL + Bcl-2-like protein

2c9w, 2izv, 2jz3, 5bo4 – hEloBC + suppressor of cytokine signaling

6c5x, 6i4x, 6i5n, 6i5j 7m6t – hEloBC + suppressor of cytokine signaling + Gp130 peptide

6i5n, 6i5j – hEloBC + suppressor of cytokine signaling + growth hormone receptor peptide

6i4x – hEloBC + suppressor of cytokine signaling + erythropoietin peptide

6p59 - hEloBC + virion infectivity factor + CBF b

3zkj - hEloBC + ankyrin rep

1vcb – hEloBC + VHL

3zng – hEloBC + ASB-9

6v9h – hEloBC + creatine kinase + ASB-9 – Cryo EM

6r6h, 6r7f, 6r7h, 6r7i, 6r7n – hEloBC in signalosome – Cryo EM

2fnj - mEloBC + GUSTAVUS

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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Elongation factor 3D structures

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3D structures of elongation factor

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