Engulfment and cell motility protein 1

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Human SeMet ELMO1 C-terminal PH domain (green) complex with DOCK2 SH3 domain (cyan) (PDB code 3a98)

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References

  1. Park YL, Cho SB, Park SY, Oh HH, Myung E, Im CM, Son S, Kim S, Cho SY, Chung MW, Hong JY, Kim KH, Myung DS, Lee WS, Park D, Joo YE. Engulfment and Cell Motility 1 (ELMO1) Regulates Tumor Cell Behavior and Predicts Prognosis in Colorectal Cancer. Anticancer Res. 2022 Nov;42(11):5343-5355. PMID:36288887 doi:10.21873/anticanres.16058
  2. Chang L, Yang J, Jo CH, Boland A, Zhang Z, McLaughlin SH, Abu-Thuraia A, Killoran RC, Smith MJ, Côté JF, Barford D. Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state. Nat Commun. 2020 Jul 10;11(1):3464. PMID:32651375 doi:10.1038/s41467-020-17271-9
  3. Kakoki M, Bahnson EM, Hagaman JR, Siletzky RM, Grant R, Kayashima Y, Li F, Lee EY, Sun MT, Taylor JM, Rice JC, Almeida MF, Bahr BA, Jennette JC, Smithies O, Maeda-Smithies N. Engulfment and cell motility protein 1 potentiates diabetic cardiomyopathy via Rac-dependent and Rac-independent ROS production. JCI Insight. 2019 Jun 20;4(12):e127660. PMID:31217360 doi:10.1172/jci.insight.127660
  4. Hanawa-Suetsugu K, Kukimoto-Niino M, Mishima-Tsumagari C, Akasaka R, Ohsawa N, Sekine S, Ito T, Tochio N, Koshiba S, Kigawa T, Terada T, Shirouzu M, Nishikimi A, Uruno T, Katakai T, Kinashi T, Kohda D, Fukui Y, Yokoyama S. Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3305-10. Epub 2012 Feb 13. PMID:22331897 doi:10.1073/pnas.1113512109

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