Function
Engulfment and cell motility protein 1 (ELMO1) or CED-12 homolog mediates tumour progression by increasing cell motility and inhibiting apoptosis in human colorectal cancer[1]. Complex formation of ELMO1 with dedicator of cytokinesis 2 (DOCK2) is necessary for DOCK2-mediated Rac signaling[2].
Disease
Studies have shown that ELMO1 polymorphism is associated with diabetic nephropathy[3].
Structural highlights
The complex of ELMO1 and DOCK2 is formed between the C-terminal of ELMO1 and the SH3 domain of DOCK2. The which includes the binding , forms a five helix bundle with the DOCK2 SH3 domain[4].
3D structures of engulfment and cell motility protein 1
Updated on 19-May-2024
6jpp – hELMO1 RBD domain 1-113 – human - NMR
7y4a – hELMO1 RBD domain + RhoG
2vsz – hELMO1 PH domain 532-727
6tgb – hELMO1 + DOCK2 – Cryo EM
3a98 – hELMO1 PH domain + DOCK2
6tgc – hELMO1 + DOCK2 + Rac1 – Cryo EM
7dpa – hELMO1 + DOCK5 + Rac1 – Cryo EM
6uka – mELMO1 RBD domain + RhoG - mouse