Eukaryotic initiation factor 3D structures

From Proteopedia

3D structures of eukaryotic initiation factor

Updated on 26-February-2023

EIF1

2if1, 1d7q – hEIF1 – human – NMR

3zjy – hEIF1A + importin 13 + RanGTP

6ybw – hEIF1A in 48S ribosome – Cryo EM

4kzx, 4kzy, 4kzz – rEIF1A in 40S ribosome – rabbit – cryo EM

6yal, 6yan – rEIF1A+rEIF2A+EIF2C in 48S ribosome – Cryo EM

2ogh - yEIF1 – yeast - NMR

3j80, 3j81, 4uer – EIF1A in 40S ribosome – Kluyveromyces lactis – cryo EM

EIF2

1kl9, 1q8k – hEIF2A subunit α

3ecs – hEIF2B subunit α

7d46, 7l70 – hEIF2B subunits α,β,γ,δ,ε – Cryo EM

6ezo – hEIF2B subunits α,β,γ,δ,ε + drug

6o9z, 6o85, 6o81, 6k72, 6k71, 6i7t, 6k71, 6k72, 6o81, 6o85, 6o9z, 7d43, 7d44, 7d45 – hEIF2B subunits α,β,γ,δ,ε + hEIF2 subunits α,β,γ – Cryo EM

7kmf – hEIF2B subunits α,β,γ,δ,ε + fructofuranose – Cryo EM

7l7g – hEIF2B subunits α,β,γ,δ,ε + inhibitor – Cryo EM

5oa9 – hEIF2D

5w2f – hEIF2D C-terminal

5oa3 – hEIF2D in 40S ribosome – Cryo EM

1q46 – yEIF2A – yeast

3wj9 - EIF2A – fission yeast

2a19, 2a1a – yEIF2A (mutant) + interferon-induced protein kinase

1paq – yEIF2B e subunit catalytic domain 524-712

6i3m, 6qg0, 6qg1, 6qg2, 6qg3, 6qg5, 6qg6 – yEIF2B + yEIF2 – Cryo EM

4zgq, 4zgn – yEIF2G residues 410-527 + CDC123

3wj9 - fyEIF2A – fission yeast

6jlz, 6jly - fyEIF2A + EIF2B

6i5m – SsEIF2 subunit γ + GDP – Sulfolobus solfataricus

6h6k, 6r8s, 6r8t – SsEIF2 subunit γ (mutant) + GDP

2a0u – EIF2B – Leihmania major

EIF2C or argonaute

5w6v – hEI2C1 + RNA + GW182

3luk – hEI2C2 mid domain 439-575

3lud, 3lug, 3luh, 3luj, 3qx8, 3qx9 - hEIF2C mid domain + nucleotide

5t7b, 5ki6, 4f3t – hEI2C2 + RNA

6ra4 – hEI2C2 PAZ domain 214-347+ RNA

4z4i, 4z4h, 4z4g, 4z4f, 4z4e, 4z4d, 4z4c, 4w5t, 4w5r, 4w5q, 4w5o, 4w5n, 4ola, 6cbd, 5wea, 5js2, 5js1, 4olb, 6n4o, 6mdz, 6mfn, 6mfr, 6n4o, 6nit – hEI2C2 (mutant) + RNA

5vm9 – hEI2C3 + RNA

6oon – hEI2C4 + RNA

EIF3

6ybd, 6ybs, 6zvj - hEIF3 in 40S ribosome – cryo EM

3j8b, 3j8c - hEIF3A + hEIF3C + hEIF3E + hEIF3F + hEIF3H + hEIF3K + hEIF3L + hEIF3M – cryo EM

6ybt - hEIF3A + hEIF3B + hEIF3I – cryo EM

6ybv - hEIF3A + hEIF3B + hEIF3C + mRNA + initiator Met tRNA – cryo EM

5a5t - rEIF3A + rEIF3C + rEIF3E + rEIF3F + rEIF3H + rEIF3K + rEIF3M – Cryo EM - rat

6zce, 6zu9, 7a1g - yEIF3 in 40S ribosome – cryo EM

4kxt, 4krf, 4kre, 1si2, 1si3 – hEI2C1 + RNA

4k51, 4u1d - yEIF3A PCI domain

4u1c - yEIF3A PCI + yEIF3C PCI

2nlw - hEIF3B RNA recognition domain – NMR

2krb - hEIF3B RNA recognition domain + hEIF3J peptide

5k1h – hEIF3B + EIF3A C-terminal

5a5u - rEIF3B + rEIF3I – Cryo EM

3ns5, 3ns6 - yEIF3B RNA recognition domain

4u1f - yEIF3B middle domain

4u1e - yEIF3B CTD + yEIF3I + yEIF3G NTD

4nox – CtEIF3B – Chaetomium thermophilum

4nox – CtEIF3B – Chaetomium thermophilum

5h7u - yEIF3C residues 36-163

5krb, 5krc, 5krd, 5k4d, 5k4c, 5k4b – EIF3D – wasp

2cq0 – hEIF3G RNA recognition domain – NMR

2mjc - hEIF3G residues 153-176 – NMR

5k0y - rEIF3G in ribosome – cryo EM

3zwl - yEIF3I + EIF3B CTD

3bpj – hEIF3J

1rz4 – hEIF3K

EIF4

2g9n, 3bor – hEIF4A DEAD domain

2hxy – hEIF4A-III

1fuk – yEIF4A CTD

1fuu - yEIF4A mRNA helicase domain

1wi8, 2j76 – hEIF4B RNA recognition domain - NMR

2gpq, 3tf2 – hEIF4E

5gw6 – hEIF4E (mutant)

2wmc - EIF4E - pea

5me7 - mmEIF4E - muskmelon

2idr – wEIF4E – wheat

1ug3 – hEIF4GI CTD (mutant)

3l6a - hEIF4GII CTD

1hu3, 3d3m, 4iul – hEIF4GII middle domain

6ozu – EIF4G5 MIF4G domain – Trypanosoma cruzi

2dng – hEIF4H RNA recognition domain – NMR

EIF4 complexes with protein

3ex7, 2xb2 – hEIF4A + MAGO homolog + RNA-binding protein 8A + CASC3 + RNA

2zu6, 3eiq – hEIF4A + programmed cell death protein

4c9b - hEIF4A + CWC22

5zbz - hEIF4A-I DEAD domain + sanguinarine

7ppz, 7pq0 - hEIF4A-I + Burkholderia lethal factor

5xln - hEIF4A-II + ThrRS

6yvh - hEIF4A-III + CWC22 + CWC27

5mqf, 5xjc, 5yzg, 6icz, 7w59, 7w5a, 7w5b - hEIF4A in splicesome – Cryo EM

5t46 - hEIF4E + EIF4GI

5nvn - hEIF4E + EIF4E-binding protein

5nvm, 5nvl, 5nvk - hEIF4E + GRB10-interacting GYF protein

5ehc, 5ei3, 5eir - hEIF4E + EIF4GI + inhibitor

7ddx - mEIF4A-I + KANK1 - mouse

2vso, 2vsx - yEIF4E + yEIF4F

6fc3 - yEIF4E + p20

6fc2, 6fc1 - yEIF4E + EAP1

4axg - DmEIF4E + protein CUP – Drosophila melanogaster

4ue8, 4uea, 4ueb, 4ued, 5abu, 5abv - DmEIF4E + 4E-binding protein

4ue9 - DmEIF4E + 4E transporter

4uec, 5t47, 5t48 - DmEIF4E + DmEIF4G

5me5 - mmEIF4E + EIF4GI

6fc0, 6fbz - CtEIF4G + EIF4E-like

EIF4 complexes with other molecules

5zc9 - hEIF4A-I + RNA + ATP analog + drug

6icz, 6qdv, 7a5p - hEIF4A-III in spliceosome – Cryo EM

5ekv - hEIF4E + 4E-BP1 peptide + inhibitor

2jgb - hEIF4E + nucleotide + 4E-BP1 peptide

4tpw, 4tqb, 4tqc - hEIF4E + nucleotide + inhibitor

4bea, 5zml, 5zk9, 5zk7, 5zk5, 5zjz, 5zjy - hEIF4E + stapled peptide

1ej1, 1l8b, 4b6u, 4b6v - mEIF4E + nucleotide

6u06, 6u09 - mEIF4E + inhibitor

6xki - mEIF4E + RNA + pateamine

1ipb, 1ipc - hEIF4E + nucleotide

4dt6, 4dum – hEIF4E + inhibitor

2w97, 4aza – hEIF4E + hEIF4G peptide

2v8w, 2v8x, 2v8y, 3u7x, 2jgc - hEIF4E + EIF4E-BP1 peptide

3am7, 1wkw - hEIF4E + EIF4E-BP1 peptide + nucleotide

1ej4 - mEIF4E + EIF4E-BP1 peptide

5osx, 5m84, 5m83, 5m81, 5m80, 5m7z, 5m7x, 5m7w, 5m7v, 5j5y, 5j5o, 6ylt, 6ylv - mEIF4E + mRNA cap analog

6ylr - mEIF4E (mutant) + mRNA cap analog

5bxv, 1ejh - mEIF4E + nucleotide + 4E-BP1 peptide

2idv - wEIF4E (mutant) + GDP

3hxg, 3hxi - EIF4E + EIF4E-BP1 peptide + GDP – Schistosoma mansoni

3m93, 3m94 - EIF4E + EIF4E-BP1 peptide + nucleotide – Pig roundworm

5abx, 5aby - EIF4E + EIF4E-BP1 peptide + nucleotide – roundworm

1ap8 – yEIF4E + GDP – NMR

1rf8 - yEIF4E + yEIF4GI peptide + GDP

4ue8, 4uea, 4ueb, 4ued, 5abu, 5abv - DmEIF4E + 4E-BP1

5me6 - mmEIF4E + GDP derivative

EIF5

3cpf - hEIF

2iu1 - hEIF5 CTD

2g2k – hEIF5 NTD (mutant) – NMR

2e9h – hEIF5 – NMR

3cpf – hEIF5A

5dlq – hEIF5A + exportin 4 + GTPase RAN + GTP

2ful – yEIF5 CTD

3er0 - yEIF5A

6q84 – yEIF5A + importin + RANGTP

5hy6 – EIF5A – armyworm

1eif, 2eif – EIF5A – Methanocaldococcus janaschii

1x6o – EIF5A – Leishmania braziliensis

1xtd - EIF5A – Leishmania mexicana

3hks – EIF5A – Arabidopsis thaliana

6knd, 6kne – EIF5 CTD – Candida albicans

6q84 – yEIF5A + importin Kap122 + GTPase RAN + GTP

3wbi, 3wbj, 4n3s – yEIF5B

3wbk – yEIF5B + yEIF1A

4ncf – yEIF5B + nucleotide

4tmt, 4tmv, 4tmw, 4tmx, 4tmz, 4tn1 – CtEIF5B (mutant) + nucleotide

EIF6

6lqm, 6lsr, 6lss, 6lu8 – hEIF6 in pre-60S ribosome – cryo EM

1g62 – yEIF6

2x7n – yEIF6S + sarcin-ricin loop + ribosomal protein L23 + ribosomal protein L24

3j2i – yEIF6 + proliferation-associated protein 2G4 – cryo EM

5m3q – CtEIF6

5anb, 5an9, 6qkl – EIF6 in 60S ribosome – slime mold – cryo EM

6em5, 6em4, 6c0f, 5z3g – yEIF6 in 60S ribosome – cryo EM