Rimantadine

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Rimantadine, also known as Flumadine, (2rlf)

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Pharmacokinetics

M2 Proton Channel Inhibitor Pharmacokinetics
Parameter Rimantadine Amantadine
Tmax (hr) 4.3 2.5
Cmax (ng/ml) 310 402
Bioavailability (%) >90 >90
Protein Binding (%) 40 67
T1/2 (hr) 27.7 ~15
AUC (ng/ml/hr) 11917 5420
Dosage (mg) 100 100
Metabolism Negligible Negligible

For Pharmacokinetic Data References, See: References

References

  1. Schnell JR, Chou JJ. Structure and mechanism of the M2 proton channel of influenza A virus. Nature. 2008 Jan 31;451(7178):591-5. PMID:18235503 doi:10.1038/nature06531


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David Canner, Alexander Berchansky

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