Formyl-CoA transferase

From Proteopedia

spinqualitylabelsall models Structure of formyl-CoA transferase complex with oxalate, CoA, HEPES buffer and Cl- ion (green) (PDB code 2vjo). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Formyl-CoA transferase (FCT) catalyzes the conversion of formyl-CoA and oxalate to formate and oxalyl-CoA. FCT takes part in the oxalate degradation pathway[1]. Structural highlights FCT structure shows . The large domain is composed of residues from the N-terminal and the C-terminal. The active site binds , and [2]. Water molecules are shown as red spheres.

3D structures of formyl-CoA transferase

Updated on 28-March-2019

1p5h – OfFCT – Oxalobacter formigenes
1t3z, 2vjn, 2vjp, 2vjq – OfFCT (mutant)
1p5r, 2vjk, 2vjl – OfFCT + CoA
1vgq, 1vgr – OfFCT (mutant) + CoA
1t4c – OfFCT + oxalyl-aspartyl anhydride + CoA
2vjm – OfFCT + aspartyl-formyl anhydride + CoA
2vjo – OfFCT (mutant) + oxalate + CoA

References

1. ↑ Ricagno S, Jonsson S, Richards N, Lindqvist Y. Formyl-CoA transferase encloses the CoA binding site at the interface of an interlocked dimer. EMBO J. 2003 Jul 1;22(13):3210-9. PMID:12839984 doi:http://dx.doi.org/10.1093/emboj/cdg333
2. ↑ Berthold CL, Toyota CG, Richards NG, Lindqvist Y. Reinvestigation of the catalytic mechanism of formyl-CoA transferase, a class III CoA-transferase. J Biol Chem. 2008 Mar 7;283(10):6519-29. Epub 2007 Dec 27. PMID:18162462 doi:10.1074/jbc.M709353200