Fructokinase

From Proteopedia

spinqualitylabelsall models Fructokinase with ADP and Fructose bound in the active site 3lm9 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Fructokinase (FRK) catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in plants, bacteria and animals. In plants and bacteria FRK regulates starch synthesis. In animals it produces oxalate and its precursors[1]. (3lm9). Water molecules shown as red spheres. Relevance Inhibitors of FRK C may block sugar-associated metabolic syndromes[2]. Disease FRK deficiency in the liver causes the inherited metabolic disorder Fructosuria[3].

3D structures of fructokinase

Updated on 07-March-2023

2qhp – FRK – Bacterioides thetaiotamicron
3ljs – XfFRK – Xylella fastidiosa
3hj6 – FRK – Halothermothrix orenii
3lki – XfFRK + ATP
3lm9 - BsFRK + ATP + fructose – Bacillus subtilis
3ohr - BsFRK + ADP
2v78, 2var – FRK – Sulfolobus solfataricus
3c8u – FRK – Silicibacter
5ey7 – VcFRK – Vibrio cholerae
5f11 – VcFRK + fructose
5f0z, 5ygg – VcFRK + fructose + ADP
5eyn – VcFRK + fructose + ADP + BeF3
7cf8, 7cfa – FRK – Mycobacterium marinum
4u7x – BaFRK – Brucella abortus
4wjm – BaFRK + AMPPNP

References

1. ↑ James HM, Williams SG, Bais R, Rofe AM, Edwards JB, Conyers RA. The metabolic production of oxalate from xylitol: activities of transketolase, transaldolase, fructokinase and aldolase in liver, kidney, brain, heart and muscle in the rat, mouse, guinea pig, rabbit and human. Int J Vitam Nutr Res Suppl. 1985;28:29-46. PMID:3009653
2. ↑ Johnson RJ, Rivard C, Lanaspa MA, Otabachian-Smith S, Ishimoto T, Cicerchi C, Cheeke PR, Macintosh B, Hess T. Fructokinase, Fructans, Intestinal Permeability, and Metabolic Syndrome: An Equine Connection? J Equine Vet Sci. 2013 Feb;33(2):120-126. PMID:23439477 doi:http://dx.doi.org/10.1016/j.jevs.2012.05.004
3. ↑ Phillips MI, Davies DR. The mechanism of guanosine triphosphate depletion in the liver after a fructose load. The role of fructokinase. Biochem J. 1985 Jun 15;228(3):667-71. PMID:2992452