Glitazone Pharmacokinetics
From Proteopedia
Glitazone Pharmacokinetics Comparison at Equivalent Dosages | |||||
---|---|---|---|---|---|
Parameter | Pioglitazone (Actos) | Rosiglitazone (Avandia) | |||
Tmax (hr) | 1.8 | 1 | |||
Cmax (ng/ml) | 617 | 361 | |||
Bioavailability (%) | 83 | 99 | |||
Protein Binding (%) | 99 | 99 | |||
T1/2 (hr) | 3-8 | 3-4 | |||
AUC (ng/ml/hr) | 6244 | 2024 | |||
IC50 (nM) | 360 | 10 | |||
Equivalent Dosage (mg) | 30 | 4 | |||
Metabolism | Hepatic (CYP2C8) | Hepatic (CYP2C8) |
For Pharmacokinetic Data References, See: References