Glutathione synthetase

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Human glutathione synthetase complex with glutathione, ADP, sulfate and Mg+2 ions (2hgs)

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3D structures of glutathione synthetase

Updated on 11-August-2021

2hgs - GSS + glutathione + ADP – human
5oes – GSS + ADP – potato
1m0t – yGSS – yeast
1m0w - yGSS + γ-glutamyl-cysteine + AMP-PNP
3ln6 – GSS – Streptococcus agalactiae
3ln7 – GSS – Pasteurella multocida
2wyo - GSS + glutathione – Trypanosoma brucei
1glv, 2glt, 1gsh – EcGSS – Escherichia coli
1gsa – EcGSS + glutathione + ADP


Reference

  1. Dinescu A, Cundari TR, Bhansali VS, Luo JL, Anderson ME. Function of conserved residues of human glutathione synthetase: implications for the ATP-grasp enzymes. J Biol Chem. 2004 May 21;279(21):22412-21. Epub 2004 Feb 27. PMID:14990577 doi:10.1074/jbc.M401334200
  2. Polekhina G, Board PG, Gali RR, Rossjohn J, Parker MW. Molecular basis of glutathione synthetase deficiency and a rare gene permutation event. EMBO J. 1999 Jun 15;18(12):3204-13. PMID:10369661 doi:10.1093/emboj/18.12.3204
  3. Polekhina G, Board PG, Gali RR, Rossjohn J, Parker MW. Molecular basis of glutathione synthetase deficiency and a rare gene permutation event. EMBO J. 1999 Jun 15;18(12):3204-13. PMID:10369661 doi:10.1093/emboj/18.12.3204


Created with the participation of John Mazella.

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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