Glycoproteins B and D

From Proteopedia

spinqualitylabelsall models Herpes virus glycoprotein B trimer complex with Na+ ion (purple) (PDB entry 2gum) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Glycoproteins B, D (gB, gD) are components of the cell-entry complex of herpes viruses[1][2]. Glycoprotein B is required after herpes simplex virus attachment but before the expression of viral proteins[3]. Glycoprotein D determines which cells can be infected by herpes simplex virus by binding to the cell receptors which mediate the viral entry[4].

3D Structures of Glycoproteins B and D

Updated on 01-July-2024

References

1. ↑ Heldwein EE, Lou H, Bender FC, Cohen GH, Eisenberg RJ, Harrison SC. Crystal structure of glycoprotein B from herpes simplex virus 1. Science. 2006 Jul 14;313(5784):217-20. PMID:16840698 doi:313/5784/217
2. ↑ Di Giovine P, Settembre EC, Bhargava AK, Luftig MA, Lou H, Cohen GH, Eisenberg RJ, Krummenacher C, Carfi A. Structure of herpes simplex virus glycoprotein d bound to the human receptor nectin-1. PLoS Pathog. 2011 Sep;7(9):e1002277. Epub 2011 Sep 29. PMID:21980294 doi:10.1371/journal.ppat.1002277
3. ↑ Cai WH, Gu B, Person S. Role of glycoprotein B of herpes simplex virus type 1 in viral entry and cell fusion. J Virol. 1988 Aug;62(8):2596-604. PMID:2839688 doi:10.1128/JVI.62.8.2596-2604.1988
4. ↑ Manoj S, Jogger CR, Myscofski D, Yoon M, Spear PG. Mutations in herpes simplex virus glycoprotein D that prevent cell entry via nectins and alter cell tropism. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12414-21. PMID:15273289 doi:10.1073/pnas.0404211101