HIV-1 Reverse Transcriptase in Complex with Nevirapine

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Crystal Structure of HIV-1 Reverse Transcriptase with DNA and the nonnucleoside inhibitor nevirapine (PDB entry 3v81)

References

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  2. Steitz, Thomas A. DNA Polymerases: Structural Diversity and Common Mechanisms. Jour. Bio. Chem. 274:17395-17398 (1999). DOI:10.1074/jbc.274.25.17395
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  5. U.S.F.&D. Administration. http://www.fda.gov/ForConsumers/byAudience/ForPatientAdvocates/HIVandAIDSActivities/ucm118915.htm
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  7. 7.0 7.1 Hsiou Y, Ding J, Das K, Clark AD Jr, Hughes SH, Arnold E. Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms. Structure. 1996 Jul 15;4(7):853-60. PMID:8805568
  8. Mui PW, Jacober SP, Hargrave KD, Adams J. Crystal structure of nevirapine, a non-nucleoside inhibitor of HIV-1 reverse transcriptase, and computational alignment with a structurally diverse inhibitor. J Med Chem. 1992 Jan;35(1):201-2. PMID:1370694
  9. 9.0 9.1 9.2 9.3 9.4 Das K, Martinez SE, Bauman JD, Arnold E. HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism. Nat Struct Mol Biol. 2012 Jan 22;19(2):253-9. doi: 10.1038/nsmb.2223. PMID:22266819 doi:10.1038/nsmb.2223
  10. Liu S, Abbondanzieri EA, Rausch JW, Le Grice SF, Zhuang X. Slide into action: dynamic shuttling of HIV reverse transcriptase on nucleic acid substrates. Science. 2008 Nov 14;322(5904):1092-7. PMID:19008444 doi:10.1126/science.1163108

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