Hepatocyte growth factor activator

From Proteopedia

spinqualitylabelsall models Human hepatocyte growth factor activator (magenta) complex with HGFA inhibitor type 1 (green) and phosphate (PDB code 1yc0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Hepatocyte growth factor activator (HGFA) is a serine protease which links tissue injury to activation of hepatocyte growth factor (HGF). HGFA converts HGF from its latent single-chain form to a heterodimeric active form. HGFA is synthesized as an inactive precursor which is converted to a heterodimer via proteolysis as a result of tissue injury[1]. Relevance Lower activity of HGFA results in impaired regeneration of damaged mucosal epithelium and may contribute to the progression of fibrotic lung cancer[2]. Structural highlights HGFA substrate binding cleft resembles other trypsin-like serine proteases with [3].

3D Structures of hepatocyte growth factor activator

Updated on 15-May-2019

1ybw – hHGFA protease domain – human
1yc0 – hHGFA protease domain + Kunitz-type protease inhibitor
2r0l, 2r0k, 2wub, 2wuc, 3k2u – hHGFA protease domain + antibody

References

1. ↑ Miyazawa K. Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor. FEBS J. 2010 May;277(10):2208-14. doi: 10.1111/j.1742-4658.2010.07637.x. Epub, 2010 Apr 2. PMID:20402766 doi:http://dx.doi.org/10.1111/j.1742-4658.2010.07637.x
2. ↑ Wu KL, Li YQ, Tabassum A, Lu WY, Aubert I, Wong CS. Loss of neuronal protein expression in mouse hippocampus after irradiation. J Neuropathol Exp Neurol. 2010 Mar;69(3):272-80. doi:, 10.1097/NEN.0b013e3181d1afe4. PMID:20142763 doi:http://dx.doi.org/10.1097/NEN.0b013e3181d1afe4
3. ↑ . PMID:157134585