Human rhinovirus

From Proteopedia

Function Human rhinovirus (HRV) are RNA viruses. The HRV capsid is composed of 4 proteins: VP1, VP2, VP3 and VP4. The capsid structure is that of a icosahedron with 60 copies of each of its viral proteins[1][2]. Disease HRV are responsible for the majority of cold-like illnesses.

Jmol._Canvas2D (Jmol) "jmolApplet1"[x] spinqualitylabelsall models Structure of human rhinovirus 14 viral proteins VP1 (sea green), VP2 (blue), VP3 (olive), VP4 (green) (PDB code 4rhv). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of human rhinovirus

Updated on 29-September-2021

Human rhinovirus 1A

1r1a – HRV1A VP1+VP2+VP3+VP4

2hwd, 2hwe, 2hwf – HRV1A VP1+VP2+VP3+VP4 + antiviral agent

Human rhinovirus 2

1fpn – HRV2 VP1+VP2+VP3+VP4

1v9u, 3dpr – HRV2 VP1+VP2+VP3+VP4 + LDL-receptor class A3

3vdd – HRV2 VP1+VP2+VP3+VP4 + antiviral agent

Human rhinovirus B5

6sk6 – HRVB5 VP1+VP2+VP3+VP4 – Cryo EM

6sk5 – HRVB5 VP1+VP2+VP3+VP4 + antiviral agent – Cryo EM

Human rhinovirus 2A

2m5t – HRV2A proteinase - NMR

7ara – HRV2A proteinase + inhibitor

Human rhinovirus 3

1rhi – HRV3 VP1+VP2+VP3+VP4

Human rhinovirus 3C

2xya, 6sk7 – HRV3C proteinase

6ffn, 6ffs, 6ku8 – HRV3C proteinase + inhibitor

Human rhinovirus 14

4rhv, 1rmu – HRV14 VP1+VP2+VP3+VP4

1r08, 2r04, 2r06, 2r07, 2rm2, 2rmu, 2rr1, 2rs1, 2rs3, 2rs5, 1r09, 1hri, 2hwb, 2hwc, 1hrv, 1na1, 1ncq – HRV14 VP1+VP2+VP3+VP4 + antiviral agent

1ruc, 1rud, 1rue, 1ruf, 1rug, 1ruh, 1rui, 1ruj, 1vrh – HRV14 VP1+VP2+VP3+VP4 (mutant) + antiviral agent

1rvf – HRV14 VP1+VP2+VP3+VP4 + antibody

1d3i – HRV14 VP1+VP2+VP3+VP4 + intercellular adhesion molecule – Cryo-EM

1k5m – HRV14 VP1+VP2/V3 of Gp120+VP3+VP4

6kyz, 6kz0 – HRV14 3C + antibody

6hlt – HRV14 + GCP60

7nul, 7num, 7nuo – HRV14 polyprotein – Cryo-EM

7nun, 7nuq – HRV14 polyprotein + polynucleotide – Cryo-EM

7bg6 – HRV14 polyprotein + RNA – Cryo-EM

7bg7 – HRV14 polyprotein + ICAM-1 – Cryo-EM

Human rhinovirus C15

6ppo, 6psf – HRVC15 VP1+VP2+VP3+VP4 + CDHR3 – Cryo EM

Human rhinovirus 16

1aym, 1ayn, 1c8m – HRV16 VP1+VP2+VP3+VP4 (mutant)

1qju, 1qjx, 1qjy - HRV16 VP1+VP2+VP3+VP4 + antiviral agent

References

1. ↑ Oliveira MA, Zhao R, Lee WM, Kremer MJ, Minor I, Rueckert RR, Diana GD, Pevear DC, Dutko FJ, McKinlay MA, et al.. The structure of human rhinovirus 16. Structure. 1993 Sep 15;1(1):51-68. PMID:7915182
2. ↑ Jacobs SE, Lamson DM, St George K, Walsh TJ. Human rhinoviruses. Clin Microbiol Rev. 2013 Jan;26(1):135-62. doi: 10.1128/CMR.00077-12. PMID:23297263 doi:http://dx.doi.org/10.1128/CMR.00077-12