HypA-HypB-HypC-HypD-HypE-HypF

From Proteopedia

HypD with Fe4S4 center (PDB code 2z1d) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function The [NiFe] hydrogenase or hydrogenase expression/formation protein contains a NiFe(CO)(CN)2 in its reaction center. HypA, HypB, HypC, HypD, HypE and HypF are required for the maturation of [NiFe] hydrogenase. HypA[1] and HypB[2] are involved in the insertion of Ni atom. HypE and HypF[3] catalyze the biosynthesis of the CN ligand. HypC and HypD[4] deliver the Fe and CO to the hydrogenase active center. For more details of HypA see Molecular Playground/HypA. 3D Structures of HypA, HypB, HypC, HypD, HypE and HypF HypA, HypB, HypC, HypD, HypE and HypF 3D structures

References

1. ↑ Atanassova A, Zamble DB. Escherichia coli HypA is a zinc metalloprotein with a weak affinity for nickel. J Bacteriol. 2005 Jul;187(14):4689-97. PMID:15995183 doi:http://dx.doi.org/10.1128/JB.187.14.4689-4697.2005
2. ↑ Olson JW, Fu C, Maier RJ. The HypB protein from Bradyrhizobium japonicum can store nickel and is required for the nickel-dependent transcriptional regulation of hydrogenase. Mol Microbiol. 1997 Apr;24(1):119-28. PMID:9140970
3. ↑ Blokesch M, Paschos A, Bauer A, Reissmann S, Drapal N, Bock A. Analysis of the transcarbamoylation-dehydration reaction catalyzed by the hydrogenase maturation proteins HypF and HypE. Eur J Biochem. 2004 Aug;271(16):3428-36. PMID:15291820 doi:http://dx.doi.org/10.1111/j.1432-1033.2004.04280.x
4. ↑ Blokesch M, Albracht SP, Matzanke BF, Drapal NM, Jacobi A, Bock A. The complex between hydrogenase-maturation proteins HypC and HypD is an intermediate in the supply of cyanide to the active site iron of [NiFe]-hydrogenases. J Mol Biol. 2004 Nov 12;344(1):155-67. PMID:15504408 doi:http://dx.doi.org/10.1016/j.jmb.2004.09.040