Image:Caspase mediated apoptosis.PNG
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Summary
Pathway 1: Tumor necrosis factor induces the upstream initiator caspases, caspase 8 and 9, Caspase 8 and 9 activate the downstream executioners, caspase 3,6 and 7, then they cleave upwards of 500 key proteins and DNA, which cause the apoptosis. Pathway 2: Tumor necrosis factor induces Mitochondria, which release cytochrome c to bind to apoptotic protease activating factor 1. Then the complex activates pro-caspase 9, which will activate caspase 9 to activate caspase 3 and finally lead the apoptosis.
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| Date/Time | User | Dimensions | File size | Comment | |
|---|---|---|---|---|---|
| (current) | 04:25, 17 April 2012 | Student (Talk | contribs) | 539×479 | 51 KB | Pathway 1: Tumor necrosis factor induces the upstream initiator caspases, caspase 8 and 9, Caspase 8 and 9 activate the downstream executioners, caspase 3,6 and 7, then they cleave upwards of 500 key proteins and DNA, which cause the apoptosis. Pathway 2 |
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