Importin 3D structures

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3D structures of importin

Updated on 02-July-2024

IPO-α

1ial – mIPO NLS-binding domain – mouse

6d7m – mIPO (mutant)

4tnm – IPO armadillo repeat domain – Arabidopsis thaliana

1bk5 – yIPO NLS-binding domain - yeast

7vps – NgIPO ARM domain 75-516 – Nakaceomyces glabratus

IPO-α complex with NLS peptide

1ejl – mIPO NLS-binding domain + SV40 large T antigen

1ejy – mIPO NLS-binding domain + nucleoplasmin

2ynr – mIPO NLS-binding domain + B54NLS

2yns – rIPO NLS-binding domain + B54NLS - rice

1bk6 – yIPO NLS-binding domain + SV40 large T antigen

1ee4 – yIPO NLS-binding domain (mutant) + c-Myc

1ee5 – yIPO NLS-binding domain (mutant) + nucleoplasmin

1un0, 2c1t – yIPO NLS-binding domain (mutant) + Nup2

5h2x, 5h2w – yIPO NLS-binding domain + ubiquitin-like specific protease

4xzr – yIPO NLS-binding domain + HEH1

4pvz – yIPO NLS-binding domain + HEH2

4rxh – NcIPO NLS-binding domain + SV40 large T antigen – Neurospora crassa

5vqi – NcIPO NLS-binding domain + NIT2

7vpt – NgIPO ARM domain + Upc2

IPO-α complex with protein

1wa5 – yIPO NLS-binding domain + GTPase Ran + IPO-α re-exporter

5t94 – yIPO NLS-binding domain + guanine nucleotide exchange factor

5mfm – yIPO NLS-binding domain + YIIIM6AII

IPO-α 1

3wpt, 8fzk – hIPO NLS-binding domain - human

4b8j – rIPO

6bvt – mIPO NLS-binding domain

4u5v, 4u5u, 4u5s, 4u5o, 4u5n, 4u5l, 4u58, 4u54 – mIPO NLS-binding domain + inhibitor

8g4j – IPO – guinea pig

IPO-α 1 complex with NLS peptide

4b18 – hIPO NLS-binding domain + telomerase reverse transcriptase

4wv6 – hIPO NLS-binding domain + TFIID

6bw0 – hIPO NLS-binding domain + Nipa virus peptide

6bw1 – hIPO NLS-binding domain + Hendra virus peptide

5w4e, 5w4f, 5w4g – hIPO NLS-binding domain + polymerase peptide

7n9h – hIPO NLS-binding domain + TDP-43 peptide

7cru – hIPO NLS-binding domain + hnRNPK peptide

8he3 – hIPO NLS-binding domain + HIF-1 peptide

7n8j – hIPO NLS-binding domain + BIMAX peptide

5h43 – hIPO NLS-binding domain + histone acetyltransferase KAT8

8gai – IPO NLS-binding domain + BIMAX peptide – guinea pig

4mz5, 4mz6 – mIPO NLS-binding domain 70-528 + dUTPase

4oih – mIPO NLS-binding domain + guanine nucleotide exchange factor SRM1

5svz – mIPO NLS-binding domain + TAT NLS motif

5wum, 5wun, 5x8n – mIPO NLS-binding domain + Epstein Barr antigen

5huw – mIPO NLS-binding domain + HSVI large terminase

5huy – mIPO NLS-binding domain + HSMV small terminase

5hhg, 5fc8 – mIPO NLS-binding domain + dengue 2 NS5

5ekg, 5ekf, 5e6q – mIPO NLS-binding domain + XPG2

5d5k – mIPO NLS-binding domain + PARP 2

7l04, 8fk3 – mIPO NLS-binding domain + adeno-associated virus

5ctt – mIPO NLS-binding domain + SART3/TIP110

5b56 – mIPO NLS-binding domain + HIV-1 VPR

4zdu – mIPO NLS-binding domain + influenza nucleoprotein

4yi0 – mIPO NLS-binding domain + Nup121

5klr, 5klt – mIPO NLS-binding domain + NLS

5k9s – mIPO NLS-binding domain + HNF-b

6iu7, 6iua – mIPO NLS-binding domain + TP53-binding protein

5w41 – mIPO NLS-binding domain + Zika virus peptide

8fua, 8fuc – mIPO NLS-binding domain + Hendra virus peptide

8ech – mIPO NLS-binding domain + tick-bourne encephalitis virus

5v5o, 5v5p – mIPO NLS-binding domain + influenza virus peptide

5umz – mIPO NLS-binding domain + TNRC6A peptide

5u5p, 5u5r, 6wba, 6wbb, 6wbc, 7m60 – mIPO NLS-binding domain + MLH1 peptide

5gxw – mIPO NLS-binding domain + NUMA peptide

6iw8, 6iwa – mIPO NLS-binding domain + GM130 peptide

6k06 – mIPO NLS-binding domain (mutant) + GM130 peptide

6mjl – mIPO NLS-binding domain + CHREBP peptide

6p6a – mIPO NLS-binding domain + NIT-2 peptide

6p6e – mIPO NLS-binding domain + PAC3 peptide

7jjm, 7jk7 – mIPO NLS-binding domain + LSD1 peptide

7jvo – mIPO NLS-binding domain + ACE2 peptide

8he0 – mIPO NLS-binding domain + HIF-1 peptide

7rg4, 7rg5 – mIPO NLS-binding domain + p50 peptide

6wx7 – mIPO NLS-binding domain + SOX2 peptide

4b8o – rIPO NLS-binding domain + SV40

4b8p – rIPO NLS-binding domain + A89

4bpl – rIPO NLS-binding domain + nucleoplasmin

4bqk – rIPO NLS-binding domain + VirD2

IPO-α 1 complex with protein

2jdq – hIPO NLS-binding domain + polymerase basic protein 2 C terminal

3tj3 – hIPO NLS-binding domain + Nup50 N terminal

2jdq – hIPO NLS-binding domain + telomerase reverse transcriptase peptide

4uaf – mIPO NLS-binding domain + influenza RNA polymerase

IPO-α 2

3tpo – mIPO

1iq1 – mIPO NLS-binding + autoinhibitory peptide domains

4e4v – hIPO NLS-binding domain (mutant)

IPO-α 2 complex with NLS peptide

1pjm – mIPO NLS-binding domain + retinoblastoma-associated protein

1pjn – mIPO NLS-binding domain + histone-binding protein N1/N2

1q1s, 1q1t – mIPO NLS-binding domain + SV40 large T antigen

1y2a, 3q5u – mIPO NLS-binding domain + phospholipid scramblase

2c1m – mIPO NLS-binding domain + Nup50

7leq – mIPO NLS-binding domain + p50

7leu – mIPO NLS-binding domain + p65

3btr – mIPO NLS-binding domain + androgen receptor

3knd – mIPO NLS-binding domain + targeting protein for KXLP2

3l3q – mIPO NLS-binding domain + library peptide

3oqs – mIPO NLS-binding domain + CLIC4

3rz9 – mIPO NLS-binding domain + KU80

3rzx – mIPO NLS-binding domain + KU70

3tpm – mIPO NLS-binding domain + MAL

3ve6 – mIPO NLS-binding domain + Venezuelan equine encephalitis virus

8f2q – mIPO NLS-binding domain + parvovirus

3uvu – mIPO NLS-binding domain + flap endonuclease

3ukw, 3ukx – mIPO NLS-binding domain + BIMAX

3uky, 3ukz, 3ul0 – mIPO NLS-binding domain + nuclear CAP-binding protein

3ul1 – mIPO NLS-binding domain + nucleoplasmin

4htv – mIPO NLS-binding domain + capsid protein

4ba3 – mIPO NLS-binding domain + A89NLS

3zio, 3zip, 3ziq, 3zir – mIPO NLS-binding domain + minor site-specific NLS

3zin – mIPO NLS-binding domain + nucleolar RNA helicase

7jjm – mIPO + LSD1 peptide

IPO-α 2 complex with protein

3fex, 3fey – mIPO NLS-binding domain + nuclear CAP-binding protein

7rfx, 7rfz, 7rg0, 7rg1, 7rg2, 7rg3, 7rg6 – mIPO + ORF4b

IPO-α 3

6bvz – hIPO NLS-binding domain

4uae – hIPO NLS-binding domain + influenza RNA polymerase

6bw9, 6bwa, 6bwb – hIPO NLS-binding domain + Hendra virus peptide

6bvv – hIPO NLS-binding domain + Nipa virus peptide

5xzx – hIPO NLS-binding domain + RAN-binding protein peptide

8hkw – hIPO NLS-binding domain + 53BP1 peptide

5tbk – hIPO NLS-binding domain + regulator of chromosome condensation

7rfy – hIPO + ORF4b

6wx8 – hIPO + SOX2

7lfc – hIPO + p50 NLS

7lf4 – hIPO + p50 NLS + p65 NLS

8fub – hIPO NLS-binding domain + Hendra virus peptide

7jjl – hIPO + LSD1 peptide

8fzm – mIPO NLS-binding domain + BIMAX

7let – mIPO + p50 NLS + p65 NLS

IPO-α 5

6wx9 – hIPO + SOX2

IPO-α 6

4u2x – hIPO C terminal + ebola VP24

IPO-α 7

7rht – hIPO

4uad – hIPO NLS-binding domain + influenza RNA polymerase

IPO-β

4xri, 4xrk – IPO – Chaetomium thermophilum

IPO-β 1 (karyopherin β 1)

3nd2 – yIPO

1gcj – mIPO N terminal

IPO-β 1 complex with protein

1qgx, 1qgk – hIPO + IPO-α 2 IBB domain

1ibr – hIPO + GTPase Ran

6n88, 6n89 – hIPO + H1.0 – Cryo EM

1f59, 1o6p, 1o6o – hIPO + FXFG nucleoporin repeats

1m5n – hIPO HEAT repeats 1-11 + parathyroid hormone-related protein NLS peptide

2p8q, 2q5d, 2qna, 3lww – hIPO + RNA U transporter N terminal

1qgr, 3w5k – hIPO + zinc finger protein SNAI1

1ukl – mIPO + SREBP-2

2bku, 3ea5 – yIPO + GTPase Ran

5owu – yIPO + Nup1

IPO-β 2 (Transportin 1)

2z5j, 2qmr – hIPO

IPO-β 2 complex with protein

2h4m, 2ot8, 2z5n – hIPO + hnRNP peptide

2z5k, 2z5m – hIPO + nuclear RNA export factor peptide

2z5o – hIPO + JKTBP peptide

4fdd, 4jlq, 4oo6 – hIPO + RNA binding protein peptide

5yvg, 5yvh – hIPO + FUS

5vyh, 5vyi – hIPO + FUS peptide

4fq3 – hIPO + FUS peptide

5tqc – hIPO + RPL4 peptide

5j3v – hIPO + histone H3 peptide

IPO-β 3 (Karyopherin β 3)

3w3t – yIPO

3w3u, 3w3v – yIPO (mutant)

3w3w – yIPO + STE12P

3w3x – yIPO + PHO4

3w3y – yIPO + Nup53P

3w3z – yIPO + RANGTP

5h2v – yIPO + ubiquitin-like specific protease

4zj7 – yIPO + CDC14

IPO-β 5 (Karyopherin β 5)

6aho – yIPO

IPO-4

8dyo – hIPO + RanGTP – Cryo EM

7unk – hIPO + H3 + H4 + ASF1 – Cryo EM

IPO-4B

5xah – hIPO residues 668-1081

5xbk – hIPO residues 668-1081 + histone H3 peptide

IPO-5

6xte, 6xu2 – hIPO + antipain peptide

IPO-7

6n88 – IPO + hIPO-90 + histone H1.0 – frog – Cryo EM

IPO-9

6n1z – hIPO + histone H2A + histone H2B

IPO-12 (Transportin-3)

4c0p – hIPO

4c0o – hIPO + serine/arginine-rich splicing factor

4c0q, 4ol0 – hIPO + GTPase Ran

6gx9 – hIPO + CPSF 68

IPO-13 (karyopherin 13)

2x19 – hIPO + GTPase Ran

2xwu – hIPO + UBC9

3zjy – hIPO + GTPase Ran + EIF-1A

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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Importin 3D structures

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3D structures of importin

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