Insulin-like growth factor 2 mRNA-binding protein

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Human IMP3 RNA-binding domain complex with RNA CCCC (colored wheat) (PDB code 6fqr).

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3D structures of insulin-like growth factor 2 mRNA-binding protein

Updated on 30-May-2023

References

  1. ↑ Bell JL, Wachter K, Muhleck B, Pazaitis N, Kohn M, Lederer M, Huttelmaier S. Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? Cell Mol Life Sci. 2013 Aug;70(15):2657-75. doi: 10.1007/s00018-012-1186-z. Epub , 2012 Oct 16. PMID:23069990 doi:http://dx.doi.org/10.1007/s00018-012-1186-z
  2. ↑ Gutschner T, Hammerle M, Pazaitis N, Bley N, Fiskin E, Uckelmann H, Heim A, Grobeta M, Hofmann N, Geffers R, Skawran B, Longerich T, Breuhahn K, Schirmacher P, Muhleck B, Huttelmaier S, Diederichs S. Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma. Hepatology. 2014 May;59(5):1900-11. doi: 10.1002/hep.26997. Epub 2014 Apr 1. PMID:24395596 doi:http://dx.doi.org/10.1002/hep.26997
  3. ↑ Dahlem C, Barghash A, Puchas P, Haybaeck J, Kessler SM. The Insulin-Like Growth Factor 2 mRNA Binding Protein IMP2/IGF2BP2 is Overexpressed and Correlates with Poor Survival in Pancreatic Cancer. Int J Mol Sci. 2019 Jun 29;20(13). pii: ijms20133204. doi: 10.3390/ijms20133204. PMID:31261900 doi:http://dx.doi.org/10.3390/ijms20133204
  4. ↑ Lin L, Zhang J, Wang Y, Ju W, Ma Y, Li L, Chen L. Insulin-like growth factor-II mRNA-binding protein 3 predicts a poor prognosis for colorectal adenocarcinoma. Oncol Lett. 2013 Sep;6(3):740-744. doi: 10.3892/ol.2013.1458. Epub 2013 Jul 12. PMID:24137402 doi:http://dx.doi.org/10.3892/ol.2013.1458
  5. ↑ Jia M, Gut H, Chao JA. Structural basis of IMP3 RRM12 recognition of RNA. RNA. 2018 Aug 22. pii: rna.065649.118. doi: 10.1261/rna.065649.118. PMID:30135093 doi:http://dx.doi.org/10.1261/rna.065649.118

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