Insulin-like growth factor 2 mRNA-binding protein

From Proteopedia

Function

Insulin-like growth factor 2 mRNA-binding proteins (IMP1, IMP2, IMP3) are important factors in cell polarization, migration, morphology, metabolism, proliferation and differentiation. IMPs are expressed mainly in embryogenesis^[1].

Relevance

IMPs are highly associated with cancer metastasis and the expression of oncogenic factors. IMP1 is protumorigenic factor in liver carcinogenesis^[2]. IMP2 is overexpressed and predicts poor prognosis in pancreatic cancer^[3]. IMP3 predicts poor prognosis for colorectal adenocarcinoma^[4].

Structural highlights

IMPs contain 2 RNA-binding regions, The N-terminal RRM12 and the C-terminal KH domains. The 3D structure of the complex between IMP3 RRM12 domain and the RNA tetranucleotide CCCC shows the π-π stacking of RNA with Phe and Tyr side-chains of IMP3^[5]. Whole RNA tetranucleotide CCCC binding site. Water molecules are shown as red spheres.

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Human IMP3 RNA-binding domain complex with RNA CCCC (colored wheat) (PDB code 6fqr).

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3D structures of insulin-like growth factor 2 mRNA-binding protein

Updated on 30-May-2023

Insulin-like growth factor 2 mRNA-binding protein 1

Insulin-like growth factor 2 mRNA-binding protein 2

Insulin-like growth factor 2 mRNA-binding protein 3

References

↑ Bell JL, Wachter K, Muhleck B, Pazaitis N, Kohn M, Lederer M, Huttelmaier S. Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? Cell Mol Life Sci. 2013 Aug;70(15):2657-75. doi: 10.1007/s00018-012-1186-z. Epub , 2012 Oct 16. PMID:23069990 doi:http://dx.doi.org/10.1007/s00018-012-1186-z
↑ Gutschner T, Hammerle M, Pazaitis N, Bley N, Fiskin E, Uckelmann H, Heim A, Grobeta M, Hofmann N, Geffers R, Skawran B, Longerich T, Breuhahn K, Schirmacher P, Muhleck B, Huttelmaier S, Diederichs S. Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma. Hepatology. 2014 May;59(5):1900-11. doi: 10.1002/hep.26997. Epub 2014 Apr 1. PMID:24395596 doi:http://dx.doi.org/10.1002/hep.26997
↑ Dahlem C, Barghash A, Puchas P, Haybaeck J, Kessler SM. The Insulin-Like Growth Factor 2 mRNA Binding Protein IMP2/IGF2BP2 is Overexpressed and Correlates with Poor Survival in Pancreatic Cancer. Int J Mol Sci. 2019 Jun 29;20(13). pii: ijms20133204. doi: 10.3390/ijms20133204. PMID:31261900 doi:http://dx.doi.org/10.3390/ijms20133204
↑ Lin L, Zhang J, Wang Y, Ju W, Ma Y, Li L, Chen L. Insulin-like growth factor-II mRNA-binding protein 3 predicts a poor prognosis for colorectal adenocarcinoma. Oncol Lett. 2013 Sep;6(3):740-744. doi: 10.3892/ol.2013.1458. Epub 2013 Jul 12. PMID:24137402 doi:http://dx.doi.org/10.3892/ol.2013.1458
↑ Jia M, Gut H, Chao JA. Structural basis of IMP3 RRM12 recognition of RNA. RNA. 2018 Aug 22. pii: rna.065649.118. doi: 10.1261/rna.065649.118. PMID:30135093 doi:http://dx.doi.org/10.1261/rna.065649.118