Interleukin 3D structures

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3D structures of interleukin

Updated on 04-June-2023

IL-1 α

2ila - hIL-1 α - human

2kki - hIL-1 α residues 121-271

2l5x – hIL-1 α residues 121-271 + calcium-binding protein A13 – NMR

IL-1 β

2nvh, 9ilb, 1iob, 5i1b, 2i1b, 4i1b, 1i1b - hIL-1 β

1tp0, 1t4q, 1too, 1twe, 1twm, 1s0l, 1l2h, 1hib, 21bi, 31bi, 41bi - hIL-1 β (mutant)

6i1b, 7i1b - hIL-1 β - NMR

3ltq - hIL-1 β residues 117-269

3pok - hIL-1 β residues 117-269 (mutant)

6y8i, 6y8m - hIL-1 β residues 117-269 + pyridine derivative

1itb - hIL-1 β + IL-1 receptor 1 extracellular domain

3o4o - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein

4dep - hIL-1 β + IL-1 receptor 1 + IL-1 receptor accessory protein

4g6j, 4g6m, 5bvp, 7chy, 7chz, 7z4t]] - hIL-1 β + antibody

2kh2 - hIL-1 β + SCFV - NMR

1md6 – mIL-1F5 – mouse

2mib, 8i1b - mIL-1 β

2wry - cIL-1 β – chicken

3nj5, 4x3a, 4x39, 4x38, 4x37 – cIL-1 β (mutant)

IL-2 (T-cell growth factor)

1m47, 1m4c, 3ink – hIL-2

3qb1, 7m2g, 7ra9, 7raa - hIL-2 (mutant)

1irl – hIL-2 (mutant) - NMR

5m5e - hIL-2 + IL-2 receptor β + cytokine receptor common γ

2erj, 2b5i - hIL-2 + IL-2 receptor α and β + cytokine receptor common γ

1z92 - hIL-2 + IL-2 receptor α

3qaz - hIL-2 + IL-2 receptor β and γ

1qvn, 1nbp, 1m4a, 1m4b – hIL-2 (mutant) + inhibitor

1pw6, 1py2, 1m48, 1m49 – hIL-2 + inhibitor

4nej, 4nem – hIL-2 + methylfuran carboxylate derivative

5lqb, 6ye3, 7dr4 - hIL-2 + antibody

7zmz - hIL-2 + CD25

4yue - mIL-2 + antibody

4yqx - IL-2 + antibody - rat

4zf7 – hIL-2 - ferret

7cjn, 7d9m – IL-2 – grass carp

IL-3

1jli – hIL-3 (mutant) – NMR

6nmy – hIL-3 + IL-3 receptor α + cytokine receptor common subunit β

5uv8, 5uwc – hIL-3 (mutant) + IL-3 receptor α

2l3o – mIL-3 residues 33-156 (mutant) - NMR

IL-4

2b8u, 1hik, 2int, 1rcb – hIL-4

2cyk, 1cyl, 1itm, 1bbn, 1bcn, 1iti, 1itl – hIL-4 - NMR

2b8x, 2b8y, 2b8z, 2b90, 2b91, 2d48, 1hzi, 1hij - hIL-4 (mutant)

5fhx - hIL-4 + antibody

1iar - hIL-4 + IL-4 receptor α (mutant)

3bpl - hIL-4 + IL-4 receptor α + cytokine receptor common γ

6oel - hIL-4 + IL-4 receptor α + cytokine receptor common γ + antibody

3qb7 - hIL-4 + cytokine receptor common γ

4ydy – hIL-4 + darpin

3bpn - hIL-4 + IL-4 receptor α + IL-13 receptor α

IL-5

1hul – hIL-5

3qt2 - hIL-5 + IL-5 receptor α (mutant)

3va2 - hIL-5 + IL-5 receptor α

3b5k – mIL-5

IL-6

1alu, 7nxz – hIL-6

1il6, 2il6 – hIL-6 - NMR

1p9m - hIL-6 + IL-6 receptor α and β

8d82 - hIL-6 + IL-6 receptor α and β – Cryo EM

5fuc - hIL-6 + IL-6 receptor α + VHH6

4j4l – hIL-6 + internalin B

4ni7, 4ni9 – hIL-6 + nucleotide aptamer

4cni, 4o9h, 4zs7 – hIL-6 + antibody

2l3y - mIL-6 residues 27-211 - NMR

1i16 – IL-6 + IL-6 receptor β - Herpesvirus 8

IL-7

3di2, 3di3 - hIL-7 residues 26-177 + IL-7 receptor α ectodomain

IL-8

6n2u – hIL-8

1il8, 2il8, 5wdz – hIL-8 - NMR

1qe6, 1icw – hIL-8 (mutant)

1ikl, 1ikm - hIL-8 (mutant) - NMR

3il8, 5d14, 4xdx – hIL-8 residues 28-99

6xmn – hIL-8 residues 28-93 + CXCR1 N-terminal - NMR

1rod - hIL-8/melanoma growth stimulating protein – NMR

1ilp, 1ilq - hIL-8 + IL-8 receptor peptide

6wzm – hIL-8 + antibody

6lfm, 6lfo– hIL-8 in G-protein coupled receptor – Cryo EM

IL-9

7ox6 – hIL-9 - NMR

7ox5 - hIL-9 + IL—9 receptor a

7ox1, 7ox2, 7ox3 - hIL-9 + antibody

7xcb – mIL-9

7ox4 – mIL-9 + antibody

IL-10

2h24, 1inr, 2ilk, 1ilk – hIL-10

1j7v – hIL-10 + IL-10 receptor α (mutant)

1y6k - hIL-10 residues 19-178 + IL-10 receptor α

4x51 – mIL-10

IL-10 viral

1vlk - hvIL-10 residues 26-170 - human herpesvirus 4

1y6m - hvIL-10 residues 26-170 + IL-10 receptor α

1y6n - hvIL-10 residues 26-170 (mutant) + IL-10 receptor α

1lqs - hvIL-10 residues 20-176 + IL-10 receptor α - human herpesvirus 5

1lk3 - hvIL-10 residues 26-175 + antibody

IL-11

4mhl - hIL-11

IL-12

1f45 - hIL-12 α and β (mutant)

1f42 - hIL-12 β P40 domain

3hmx - hIL-12 α and β+ antibody

5mj3, 5mj4, 5njd - hIL-12 β + hIL-23 α + antibody

5mzv - hIL-12 β + hIL-23 α + hIL-23 receptor + antibody

6wdq - hIL-12 β + hIL-23 α + hIL-12 receptor + hIL-23 receptor

5mxa - hIL-12 β + hIL- 23 α

5mj3, 5mj4 - hIL-12 β + hIL-23 α + alphabody MB3

3qwr - hIL-12 β + hIL- 23 α + adnectin

6uib - hIL-12 β + hIL- 23 α + peptide

6sff, 6smc, 6sp3, 7pur, 7r3n - mIL-12 β

IL-13

1ijz, 1ik0 – hIL-13 – NMR

1ga3 - hIL-13 residues 21-132 - NMR

3l5w, 3l5x, 3g6d, 4i77, 4ps4 - hIL-13 residues 35-146 + antibody

3lb6 - hIL-13 + IL-13 receptor α2

3bpo, 5e4e - hIL-13 residues 20-145 + IL-4 receptor α + IL-13 receptor α

5l6y, 7rew - hIL-13 + antibody

IL-15

2xqb – hIL-15 + antibody

2psm, 2z3q, 2z3r - hIL-15 + IL-15 receptor α

4gs7 - hIL-15 + IL-15 receptor α + IL-2 receptor β,γ

IL-16

1i16 – hIL-16 - NMR

1x6d – hIL-16 PDZ domain – NMR

IL-17

4hr9 - hIL-17A (mutant)

5n92 - hIL-17A + hIL-17F

7uwm - hIL-17A + IL-17A receptor α – Cryo EM

4hsa - hIL-17A (mutant) + IL-17A receptor α

5nan - hIL-17A + hIL-17F + IL-17A receptor α

7uwn - hIL-17A + IL-17A receptor α + IL-17A receptor gamma

7zan - hIL-17A (mutant) + IL-17A receptor α + IL-17A receptor gamma

2vxs, 4qhu, 6wio, 6wir, 7wkx, 7z2m - hIL-17A + antibody

8b7w, 8dy1, 8dy5 - hIL-17A + scFv

8dyf, 8dyg, 8dyh, 8dyi - hIL-17A + inhibitor

5vb9 - hIL-17A + peptide inhibitor

7ama, 7amg - hIL-17A + modulator

5hi5, 5hi4, 5hi3, 5hhx, 5hhv - hIL-17A + peptide inhibitor + antibody

1jpy, 6hgo – hIL-17F

6ppg – hIL-17F + antibody

3jvf, 6hg4, 6hg9 - hIL-17F + IL-17 receptor α

IL-18 (Interferon-γ inducing factor)

3wo2 – hIL-18

4xfu, 4xft, 4xfs - hIL-18 (mutant)

1j0s – hIL-18 - NMR

4hjj - hIL-18 + antibody

2vxt - hIL-18 (mutant) + antibody

3f62 - hIL-18 residues 37-193 (mutant) + IL-18 binding protein

4eee, 4ekx - hIL-18 (mutant) + 14L protein

3wo3, 4r6u - hIL-18 + IL-18 receptor

3wo4 - hIL-18 + IL-18 receptor + IL-18 receptor accessory protein

IL-19

1n1f – hIL-19

IL-20

4doh - hIL-20 + IL-20 receptor α,β

IL-21

2oqp– hIL-21 – NMR

3tgx - hIL-21 + IL-21 receptor α (mutant)

IL-22

1ykb, 1m4r – hIL-22

3g9v - hIL-22 residues 29-179 + IL-22 receptor α2

3dlq, 3dgc - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1

3q1s - hIL-22 residues 29-179 (mutant) + antibody

6weo - hIL-22 + IL-22 receptor + IL-10 receptor

4o6k – IL-22 – zebra fish

IL-23

3d87 - hIL-23 α

3d85 - hIL-23 α + antibody

4grw - hIL-23 α + + hIL-12 β + nanobody

3duh - hIL-23 α + hIL-12 β

IL-24

6gg1 - hIL-24

6df3 - hIL-24 + IL—22 receptor α1 + IL-20 receptor β

IL-25

7uwj, 7uwk - hIL-25 + IL—17 receptor b – Cryo EM

7uwl - hIL-25 + IL—17 receptor a + IL—17 receptor b – Cryo EM

IL-27

7u7n, 8d85 - hIL-27 + IL—27 receptor a + IL-6 receptor b – Cryo EM

7zxk - hIL-27 + antibody

7zg0 - mIL-27 + IL—27 receptor a

7z0l - mIL-27 + IL—27 receptor a + IL-6 receptor b – Cryo EM

IL-28

3hhc – hIL-28B

5t5w - hIL-28B + IL—10 receptor β + IL-28 receptor α

IL-29

3og4, 3og6 – hIL-29 + IL-28 receptor α

IL-33

2kll - hIL-33 residues 110-270 - NMR

4kc3 - hIL-33 + IL—1 receptor-like 1

5iv4 - mIL-33 + IL—1 receptor-like 1 + IL-1 receptor accessory protein

IL-34

4dkc - hIL-34

4dkd - hIL-34 active core + macrophage colony-stimulating factor 1 receptor

4dke, 4dkf - hIL-34 active core + antibody

4exn - mIL-34

4exp - mIL-34 active core + macrophage colony-stimulating factor 1 receptor

IL-36

6hpi - hIL-36 α - NMR

4ize - hIL-36 γ

6p9e - hIL-36 γ + antagonist

IL-37

6ncu, 5hn1 - hIL-37

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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Interleukin 3D structures

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3D structures of interleukin

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