Interleukin receptor 3D structures
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3D structures of interleukin receptor
Updated on 04-June-2023
Interleukin receptor type I
Interleukin-1 receptor
4gaf
– hIL1R + EBI-005 - human
1g0y
– hIL1R + peptide
4dep
- hIL1R + hIL1 β + IL1 receptor accessory protein
Interleukin-2 receptor
1z92
– hIL2R α subunit + IL2
5m5e
- hIL2R β subunit + IL2 + cytokine receptor common subunit γ
2b5i
- hIL2R α+β+γ subunits + IL2
3qaz
,
6dg5
- hIL2R β+γ subunits + IL2
2erj
- hIL2R α (mutant)+β+γ (mutant) subunits + IL2 (mutant)
3qb7
- hIL2R γ (mutant) subunit + IL2
8epa
- hIL2R γ subunit + antibody – Cryo EM
3iu3
,
3nfp
- hIL2R α subunit + antibody
Interleukin-3 receptor
4jzj
– hIL3R α subunit + antibody
5uv8
,
5uwc
– hIL3R α subunit (mutant) + IL3
6nmy
– hIL3R α subunit (mutant) + IL3 + cytokine receptor common subunit b
4qqv
- mIL6R β subunit (mutant) - mouse
Interleukin-4 receptor
1iar
- hIL4R α (mutant) subunit + IL4
3bpl
- hIL4R α + γ subunits + IL4
3bpn
- hIL4R α subunit + hIL13R α subunit + IL4
3bpo
- hIL4R α subunit + hIL13R α subunit + IL13
6oel
- hIL4R α subunit + hIL2R γ subunit + IL4 + antibody
Interleukin-5 receptor
3qt2
– hIL5R α (mutant) subunit + IL5
3va2
- hIL5R α subunit + IL5
6h41
- hIL5R α subunit + peptide ihibitor
Interleukin-6 receptor or gp130
1i1r
– hIL6R β subunit + IL6 homolog
1pvh
- hIL6R β subunit + leukemia inhILbitory factor
3l5i
,
3l5j
,
3l5h
- hIL6R β subunit
1n26
- hIL6R α subunit
2arw
- hIL6R α subunit - NMR
1p9m
- hIL6R α + β subunits + IL6
7dc8
– hIL6R α subunit + antibody
5fuc
- mI6R α subunit + IL6 +VHH6
2hmh
- mI6R β subunit + suppressor of cytokine signaling 3
4gl9
- mI6R β subunit + suppressor of cytokine signaling 3 + tyrosine-protein kinase
Interleukin-7 receptor
3up1
- hIL7R α subunit
3di2
,
3di3
– hIL7R α (mutant) subunit + IL7 (mutant)
6p50
,
6p67
- hIL7R α subunit + antibody
4nn5
,
4nn6
,
4nn7
,
5j12
,
5j11
- mIL7R α subunit + thymic stromal lymphopoietin + cytokine receptor-like factor 2
Interleukin-10 receptor
5t5w
- hIL10 (mutant) + interferon λ receptor 21 + interferon λ-3 subunit
Interleukin-11 receptor
6o4p
– hIL11R α subunit
Interleukin-13 receptor
3lb6
- hIL13R α2 (mutant) subunit + IL13
4hwb
- hIL13R α1 subunit + antibody
5e4e
- hIL13R α1 subunit + IL4R α subunit + IL13
Interleukin-15 receptor
2ers
- hIL15R α subunit sushIL domain – NMR
2z3q
,
2z3r
,
2psm
- hIL15R α subunit + IL15
4gs7
- hIL15R α subunit + IL15 + hIL2R β,γ subunits
Interleukin-17 receptor
4nux
- hIL17RA SEFIR domain
5n9b
- hIL17RA extracellular domain
3jvf
- hIL17RA extracellular domain + IL17F
5nan
- hIL17RA + IL17A + IL17F
4hsa
- hIL17RA (mutant) + IL17A
6hg4
,
6hg9
- hIL17RC (mutant) + IL17F
6hga
- hIL17RC D2-D4 domains (mutant) + antibody
3vbc
– mIL17RB
Interleukin-18 receptor
3wo3
,
4r6u
- hIL18 receptor + hIL18
3wo4
- hIL18 receptor + hIL18 + IL18 receptor accessory protein
Interleukin-21 receptor
4nzd
– hIL21R
3tgx
– hIL21R extracellular domain (mutant) + IL21
7kq7
– hIL21R + antibody
Interleukin-23 receptor
5mzv
– hIL23R + IL12 + IL23 + nanobody
Interleukin receptor type II
Interleukin-10 receptor
1j7v
– hIL10R α (mutant) subunit + IL10
1lqs
,
1y6m
,
1y6n
- hIL10R α (mutant) subunit + IL10 homolog
1y6k
- hIL10R α (mutant) subunit + IL10
3lqm
- hIL10R β (mutant) subunit
6x93
- hIL10R + IL10 – Cryo EM
5t5w
- hIL10R (mutant) + interferon l receptor 1 + interferon l-3
Interleukin-20 receptor
4doh
- hIL20R α,β subunit + IL20
Interleukin-22 receptor
3g9v
- hIL22R α subunit + IL22
3dgc
– hIL22R α (mutant) subunit + IL22
3dlq
- hIL22R α (mutant) subunit + IL2 (mutant)
6df3
- hIL22R α subunit + hIL20R β subunit + IL24
Interleukin-28 receptor
3og4
,
3og6
- hIL28R α subunit + IL29
Interleukin receptor of immunoglobulin family
Interleukin-1 receptor (CD121a, CD121b)
1itb
– hI1R1 extracellular domain + IL1 β
1ira
- hI1R1 extracellular domain + I1R1A
1g0y
- hI1R1 extracellular domain + I1R1A peptide
3o4o
- hI1R2 + IL1 β
4dep
– hIL1R1 extracellular domain + IL1 β + + IL1 accessory protein
4gaf
– hIL1R1 extracellular domain + IL1β/IL1RA
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Michal Harel
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