Isopropylmalate isomerase

From Proteopedia

3-isopropylmalate isomerase small subunit (PDB code 1v7l) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Isopropylmalate isomerase (IPMI) catalyzes a stereo-specific isomerization of 3-isopropylmalate by dehydration followed by rehydration at a different position to 2-isopropylmalate. IPMI is a homodimer composed of a large subunit (LeuC) and a small subunit (LeuD)[1].

3D structures of Isopropylmalate isomerase

Updated on 19-October-2017

1v7l – PhIPMI small subunit – Pyrococcus horikoshii
2hcu – SmIPMI small subunit – Streptococcus mutans
3q3w – CjIPMI small subunit – Campylobacter jejuni
3vba, 2pkp – MjIPMI small subunit – Methanocaldococcus janaschii
4kp1, 4nqy – MjIPMI large subunit
3h5e, 3h5h, 3h5j – MtIPMI small subunit – Mycobacterium tuberculosis

References

1. ↑ Yasutake Y, Yao M, Sakai N, Kirita T, Tanaka I. Crystal structure of the Pyrococcus horikoshii isopropylmalate isomerase small subunit provides insight into the dual substrate specificity of the enzyme. J Mol Biol. 2004 Nov 19;344(2):325-33. PMID:15522288 doi:10.1016/j.jmb.2004.09.035