Latrophilin

From Proteopedia

spinqualitylabelsall models Human latrophilin-3 olfactomedin domain (magenta) complex with leucine-rich repeat transmembrane protein 3 (blue) and Ca+2 ion (green) (PDB code 5cmn) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Latrophilin (LAT) or adhesion G protein-coupled receptor is the major brain receptor for α-latroxin - a black widow spidertoxin which stimulates strong neuronal exocytosis in vertebrates[1]. LAT is cleaved proteolitically into 2 fragments which reassociate upon binding an agonist and upon reassociation cause release of calcium from intracellular stores and massive release of neurotransmitter. Latrophilin-1 is required for some inhibitory synaptic connections [2]. Latrophilin-3 mediates synapse formation in the hypoccampus[3]. Disease LAT-3 variant confers susceptibility to ADHD and predicts effectiveness of stimulant medication[4]. Structural highlights The high-affinity of the LAT-3/FLRT3 complex is achieved by a combination of interactions between the [5]. .

3D structures of latrophilin

Updated on 10-July-2024

References

1. ↑ Silva JP, Ushkaryov YA. The latrophilins, "split-personality" receptors. Adv Exp Med Biol. 2010;706:59-75. PMID:21618826
2. ↑ Matúš D, Lopez JM, Sando RC, Südhof TC. Essential Role of Latrophilin-1 Adhesion GPCR Nanoclusters in Inhibitory Synapses. J Neurosci. 2024 Jun 5;44(23):e1978232024. PMID:38684366 doi:10.1523/JNEUROSCI.1978-23.2024
3. ↑ Wang S, DeLeon C, Sun W, Quake SR, Roth BL, Südhof TC. Alternative splicing of latrophilin-3 controls synapse formation. Nature. 2024 Feb;626(7997):128-135. PMID:38233523 doi:10.1038/s41586-023-06913-9
4. ↑ Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D, Domene S, Velez JI, Karkera JD, Balog J, Berg K, Kleta R, Gahl WA, Roessler E, Long R, Lie J, Pineda D, Londono AC, Palacio JD, Arbelaez A, Lopera F, Elia J, Hakonarson H, Johansson S, Knappskog PM, Haavik J, Ribases M, Cormand B, Bayes M, Casas M, Ramos-Quiroga JA, Hervas A, Maher BS, Faraone SV, Seitz C, Freitag CM, Palmason H, Meyer J, Romanos M, Walitza S, Hemminger U, Warnke A, Romanos J, Renner T, Jacob C, Lesch KP, Swanson J, Vortmeyer A, Bailey-Wilson JE, Castellanos FX, Muenke M. A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication. Mol Psychiatry. 2010 Nov;15(11):1053-66. doi: 10.1038/mp.2010.6. Epub 2010 Feb, 16. PMID:20157310 doi:http://dx.doi.org/10.1038/mp.2010.6
5. ↑ Lu YC, Nazarko OV, Sando R 3rd, Salzman GS, Sudhof TC, Arac D. Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Structure. 2015 Jul 28. pii: S0969-2126(15)00277-4. doi:, 10.1016/j.str.2015.06.024. PMID:26235030 doi:http://dx.doi.org/10.1016/j.str.2015.06.024