M2 Proton Channel Inhibitor Pharmacokinetics

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M2 Proton Channel Inhibitor Pharmacokinetics
Parameter Rimantadine Amantadine
Tmax (hr) 4.3 2.5
Cmax (ng/ml) 310 402
Bioavailability (%) >90 >90
Protein Binding (%) 40 67
T1/2 (hr) 27.7 ~15
AUC (ng/ml/hr) 11917 5420
Dosage (mg) 100 100
Metabolism Negligible Negligible

For Pharmacokinetic Data References, See: References

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David Canner

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