Mitogen-activated protein kinase kinase kinase

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Mitogen-activated protein kinase kinase kinase 3 (green) complex with MAP2K5 PHOX domain (grey) (PDB code 2o2v).

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3D Structures of Mitogen-activated protein kinase kinase kinase

Updated on 11-July-2024

References

  1. Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U. Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative. J Biol Chem. 1997 Jan 31;272(5):2668-74. PMID:9006902
  2. Pham TT, Angus SP, Johnson GL. MAP3K1: Genomic Alterations in Cancer and Function in Promoting Cell Survival or Apoptosis. Genes Cancer. 2013 Nov;4(11-12):419-26. PMID:24386504 doi:10.1177/1947601913513950
  3. An Y, Cai B, Chen J, Lv N, Yao J, Xue X, Tu M, Tang D, Wei J, Jiang K, Wu J, Li Q, Gao W, Miao Y. MAP3K10 promotes the proliferation and decreases the sensitivity of pancreatic cancer cells to gemcitabine by upregulating Gli-1 and Gli-2. Cancer Lett. 2013 Feb 28;329(2):228-35. PMID:23178452 doi:10.1016/j.canlet.2012.11.005
  4. Hamdan TA, Bhat H, Cham LB, Adomati T, Lang J, Li F, Murtaza A, Hardt C, Lang PA, Duhan V, Lang KS. Map3k14 as a Regulator of Innate and Adaptive Immune Response during Acute Viral Infection. Pathogens. 2020 Feb 4;9(2):96. PMID:32033109 doi:10.3390/pathogens9020096
  5. Santen RJ, Song RX, McPherson R, Kumar R, Adam L, Jeng MH, Yue W. The role of mitogen-activated protein (MAP) kinase in breast cancer. J Steroid Biochem Mol Biol. 2002 Feb;80(2):239-56. PMID:11897507

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