NAD kinase

From Proteopedia

NAD kinase complex with NADP and sulfate (PDB code 1z0u) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function NAD kinase or ATP-dependent NAD kinase (NADK) catalyzes the conversion of ATP and NAD to ADP and NADP. NADP is critical for metabolism, calcium signaling and anti-inflammatory processes. NADK is regulated by calmodulin-dependent mechanism[1]. See NAD and NAD(P)H. Structural highlights in a cleft between the N and C-terminal domains in the dimer interface[2]. Water molecules are shown as red spheres.

3D structures of NAD kinase

Updated on 11-July-2023

References

1. ↑ Ohashi K, Kawai S, Murata K. Identification and characterization of a human mitochondrial NAD kinase. Nat Commun. 2012;3:1248. doi: 10.1038/ncomms2262. PMID:23212377 doi:http://dx.doi.org/10.1038/ncomms2262
2. ↑ Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH. Crystal structures of an NAD kinase from Archaeoglobus fulgidus in complex with ATP, NAD, or NADP. J Mol Biol. 2005 Nov 25;354(2):289-303. Epub 2005 Sep 30. PMID:16242716 doi:10.1016/j.jmb.2005.09.026