Neuraminidase Inhibitor Pharmacokinetics
From Proteopedia
Neuraminidase Inhibitor Pharmacokinetics | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Parameter | Zanamivir | Oseltamivir | |||||||||
Tmax (hr) | 1.25 | 1.5 | |||||||||
Cmax (ng/ml) | 31.6 | 57 | |||||||||
Bioavailability (%) | 2 | 75 | |||||||||
Protein Binding (%) | 10 | 42 | |||||||||
T1/2 (hr) | 3 | 3.2 | |||||||||
AUC (ng/ml/hr) | 185 | 204 | |||||||||
Clearance (L/h) | 54.1 | 18.8 | |||||||||
Dosage (mg) | 10 | 300 | |||||||||
Metabolism | None | Hepatic |
For References to Pharmacokinetic data, see: References