Function
Pannexin (PNX) is a family of single membrane channel-forming glycoprotein. The family is comprised of 3 members. PNX1 is expressed in mammalian tissue and plays a role in releasing signals for apoptotic cell clearance. In addition, PNX1 plays a role in propagation of calcium waves, regulation of vascular tone, mucociliary lung clearance, taste-bud function[1]. PNX1 mediates release of ATP which acts as a signal recruiting macrophages to apoptotic cells. PNX1 activation requires cleavage of its C-terminal tail by caspase[2].
Relevance
PNX1 acts like a tumor suppressor in glioma and is involved in melanoma, epilepsy, glaucoma, hypertension. Alzheimer, diabetes and other diseases[3].
Structural highlights
The 3D structure of human . The C-terminal of PNX1 is cleaved by caspase to produce an active PNX1. The pore transmembrane domains are occupied by [4].
3D structures of pannexin
Updated on 21-August-2023
6ltn, 6lto, 6m02, 6m66, 6v6d, 7dwb, 7f8j, 7f8n, 7f8o – hPNX1 residues 1-426 – human - Cryo EM
6m67, 6m68 – hPNX1 (mutant) residues 1-426 – Cryo EM
7wsv – hPNX1 residues 21-426 – Cryo EM
6wbf, 6wbg, 6wbk – hPNX1 residues 1-373 – Cryo EM
6wbi, 6wbl, 6wbm, 6wbn – hPNX1 (mutant) residues 1-373 – Cryo EM
7xlb, 8f7c – hPNX2 - Cryo EM
7xl6 – hPNX3 - Cryo EM
8a3b – mPNX1 – mouse - Cryo EM
6uzy, 6vd7 – PNX1 – western clawed frog – Cryo EM
