Pharmaceutical Drugs

From Proteopedia

(Redirected from Pharmaceutical drugs)
Jump to: navigation, search
AstraZeneca’s Nexium
AstraZeneca’s Nexium

The Pharmaceutical industry is one of the world’s largest industries, grossing well over $300 billion in the United States alone. Understanding how the drugs the pharma industry develops work and different characteristics of these compounds is important to nearly everyone as 50% of the US population takes at least one prescription medication regularly and nearly everyone takes a pharmaceutical pill at some point in their life.[1] The following is a growing list of pharmaceutical compounds organized by disorder.

See Pharmaceutical Drug Targets for a list of drug targets organized by disease.

The majority of all modern medicinal drugs target members of the superfamily of proteins called the G protein-coupled receptors or GPCRs[2][3].

Treatments

The following is a list of pharmaceutical treatments for various diseases, organized by disorder. Each entry highlights general information about the therapeutic, pharmacokinetic data comparisons within its drug class, and a structural analysis explaining how the drug compound functions in vivo.

Alzheimer's Disease

Bacterial Infection

Cancer
Acetylcholinesterase Inhibitors
Antagonists at glutamatergic NMDA receptors
Macrolide Antibiotics
  • Biaxin: - Generic: Clarithromycin
  • Dynabac - Generic: Dirithromycin
  • Ketek - Generic: Telithromycin
  • Llosone - Generic: Erythromycin
  • Rulide - Generic: Roxithromycin
  • Zithromax - Generic: Azithromycin
  • Invanz (Ertapenem) - Generic: Ertapenem
  • Ciprofloxacin
  • CEN-101
Anti-CD20 Monoclonal Antibody
Anti-melanoma Monoclonal Antibody
B-Raf Kinase Inhibitor
  • Zelboraf - Generic: Vemurafenib (Formerly: PLX-4032)
Chemotherapy
Dihydrofolate Reductase Inhibitor
  • Alimta - Generic: Pemetrexed
  • Folotyn - Generic: Pralatrexate
  • Methotrexate
  • Raltitrexed
Epidermal Growth Factor Receptor Inhibitor
Estrogen Receptor Modulator
  • Evista - Generic: Raloxifene
  • Fareston - Generic: Toremifene
  • Nolvadex - Generic: Tamoxifen
mTOR inhibitor
  • Rapamune - Generic: Sirolimus (Rapamycin)
  • Afinitor - Generic: Everolimus
  • Torisel - Generic: Temsirolimus
Multiple Receptor Tyrosine kinase (VEGFR, PDGFR, EGFR, KIT, Abl) Inhibitor
Vascular Endothelial Growth Factor Inhibitor

Depression

Diabetes

Erectile Dysfunction

Serotonin Transporter Inhibitors

Tricyclic Antidepressants
Selective Serotonin Reuptake Inhibitors


Dipeptidyl Peptidase-4 Inhibitor
Peroxisome Proliferator-Activated Receptor Agonist
Phosphodiesterase Type 5 Inhibitor
  • Cialis - Generic: Tadalafil
  • Levitra - Generic: Vardenafil
  • Viagra - Generic: Sildenafil

Hypercholeseterolemia

Hypertension

HIV
HMG-CoA Reductase Inhibitors (Statins)
Angiotensin-Converting Enzyme Inhibitors
β-Adrenergic Receptor Antagonists
  • Betoptic - Generic: Betaxolol
  • Blocadren - Generic: Timolol
  • Bystolic - Generic: Nebivolol
  • Coreg - Generic: Carvedilol
  • Gubernal - Generic: Alprenolol
  • Inderal - Generic: Propranolol
  • Lopressor - Generic: Metroprolol
  • Trandate - Generic: Labetalol
  • Visken - Generic: Pindolol
  • Zebeta - Generic: Bisoprolol
Chemokine Receptor Type 5 (CCR5) Inhibitors
  • Selzentry - Generic: Maraviroc
HIV-Protease Inhibitors
Non-Nucleoside Reverse Transcriptase Inhibitors
  • Intelence - Generic: Etravirine
  • Rescriptor - Generic: Delvirdine
  • Sustiva - Generic: Efavirenz
  • Viramune - Generic: Nevirapine
Nucleoside Analog Reverse Transcriptase Inhibitors
  • Baraclude - Generic: Entecavir
  • Emtriva - Generic: Emtricitabine
  • Epivir - Generic: Lamivudine
  • Hivid - Generic: Zalcitabine
  • Retrovir - Generic: Zidovudine
  • Videx - Generic: Didanosine
  • Viread - Generic: Tenofovir
  • Zerit - Generic: Stavudine
  • Ziagen - Generic: Abacavir
Retroviral Integrase Inhibitors


Inflammation & Arthritis

Influenza

Opioid drugs
Cyclooxygenase Inhibitors
  • Advil - Generic: Ibuprofen
  • Aleve - Generic: Naproxen
  • Ansaid - Generic: Flurbiprofen
  • Aspirin - Generic: Acetylsalicylic Acid
  • Bextra - Generic: Valdecoxib
  • Celebrex - Generic: Celecoxib
  • Clinoril - Generic: Sulindac
  • Daypro - Generic: Oxaprozin
  • Feldene - Generic: Piroxicam
  • Relafen - Generic: Nabumetone
  • Paracetamol - Generic: Acetaminophen
  • Ponstel - Generic: Mefanamic Acid
  • Toradol - Generic: Ketorolac
  • Vioxx - Generic: Rofecoxib
  • Voltaren - Generic: Diclofenac
Phospholipase A2 Inhibitors
  • Voltaren - Generic: Diclofenac also may inhibit phospholipase A2 as part of its mechanism of action.
M2 Proton Channel Inhibitors
Neuraminidase Inhibitors
Opioid receptors agonists
  • MScontin, Oramorph, Sevredol - Generic: Morphine (opioid receptor agonist)
  • Demerol - Generic: Meperidine (opioid receptor agonist)
  • Dolophine - Generic: Methadone (Levomethadone (the R enantiomer) is a opioid receptor agonist)
  • Actiq, Duragesic, Fentora - Generic: Fentanyl (opioid receptor agonist)
Opioid receptors antagonists
  • Narcan - Generic: Naloxone (competitive opioid receptor antagonist)
  • ReVia - Generic: Naltrexone (competitive opioid receptor antagonist)
  • Entereg - Generic: Alvimopan (opioid receptor antagonist)


References

  1. ↑ http://www.npr.org/blogs/health/2010/09/03/129626052/a-portrait-of-health-prescription-drugs-in-america
  2. ↑ Overington JP, Al-Lazikani B, Hopkins AL. How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. PMID:17139284 doi:10.1038/nrd2199
  3. ↑ Peeters MC, van Westen GJ, Li Q, IJzerman AP. Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation. Trends Pharmacol Sci. 2011 Jan;32(1):35-42. PMID:21075459 doi:10.1016/j.tips.2010.10.001


Proteopedia Page Contributors and Editors (what is this?)

David Canner, Alexander Berchansky, Karsten Theis, Wayne Decatur

Retrieved from "http://proteopedia.org/wiki/index.php/Pharmaceutical_Drugs"
Personal tools