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The Pharmaceutical industry is one of the world’s largest industries, grossing well over $300 billion in the United States alone. Understanding how the drugs the pharma industry develops work and different characteristics of these compounds is important to nearly everyone as 50% of the US population takes at least one prescription medication regularly and nearly everyone takes a pharmaceutical pill at some point in their life.[1] The following is a growing list of pharmaceutical compounds organized by disorder.
See Pharmaceutical Drug Targets for a list of drug targets organized by disease.
The majority of all modern medicinal drugs target members of the superfamily of proteins called the G protein-coupled receptors or GPCRs[2][3].
Treatments
The following is a list of pharmaceutical treatments for various diseases, organized by disorder. Each entry highlights general information about the therapeutic, pharmacokinetic data comparisons within its drug class, and a structural analysis explaining how the drug compound functions in vivo.
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Antagonists at glutamatergic NMDA receptors
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Macrolide Antibiotics
- Biaxin: - Generic: Clarithromycin
- Dynabac - Generic: Dirithromycin
- Ketek - Generic: Telithromycin
- Llosone - Generic: Erythromycin
- Rulide - Generic: Roxithromycin
- Zithromax - Generic: Azithromycin
- Invanz (Ertapenem) - Generic: Ertapenem
- Ciprofloxacin
- CEN-101
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B-Raf Kinase Inhibitor
- Zelboraf - Generic: Vemurafenib (Formerly: PLX-4032)
Chemotherapy
- Alimta - Generic: Pemetrexed
- Folotyn - Generic: Pralatrexate
- Methotrexate
- Raltitrexed
Estrogen Receptor Modulator
- Evista - Generic: Raloxifene
- Fareston - Generic: Toremifene
- Nolvadex - Generic: Tamoxifen
mTOR inhibitor
- Rapamune - Generic: Sirolimus (Rapamycin)
- Afinitor - Generic: Everolimus
- Torisel - Generic: Temsirolimus
Multiple Receptor Tyrosine kinase (VEGFR, PDGFR, EGFR, KIT, Abl) Inhibitor
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Depression
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Erectile Dysfunction
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Tricyclic Antidepressants
Selective Serotonin Reuptake Inhibitors
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Dipeptidyl Peptidase-4 Inhibitor
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Phosphodiesterase Type 5 Inhibitor
- Cialis - Generic: Tadalafil
- Levitra - Generic: Vardenafil
- Viagra - Generic: Sildenafil
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- Betoptic - Generic: Betaxolol
- Blocadren - Generic: Timolol
- Bystolic - Generic: Nebivolol
- Coreg - Generic: Carvedilol
- Gubernal - Generic: Alprenolol
- Inderal - Generic: Propranolol
- Lopressor - Generic: Metroprolol
- Trandate - Generic: Labetalol
- Visken - Generic: Pindolol
- Zebeta - Generic: Bisoprolol
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Chemokine Receptor Type 5 (CCR5) Inhibitors
- Selzentry - Generic: Maraviroc
- Intelence - Generic: Etravirine
- Rescriptor - Generic: Delvirdine
- Sustiva - Generic: Efavirenz
- Viramune - Generic: Nevirapine
- Baraclude - Generic: Entecavir
- Emtriva - Generic: Emtricitabine
- Epivir - Generic: Lamivudine
- Hivid - Generic: Zalcitabine
- Retrovir - Generic: Zidovudine
- Videx - Generic: Didanosine
- Viread - Generic: Tenofovir
- Zerit - Generic: Stavudine
- Ziagen - Generic: Abacavir
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- Advil - Generic: Ibuprofen
- Aleve - Generic: Naproxen
- Ansaid - Generic: Flurbiprofen
- Aspirin - Generic: Acetylsalicylic Acid
- Bextra - Generic: Valdecoxib
- Celebrex - Generic: Celecoxib
- Clinoril - Generic: Sulindac
- Daypro - Generic: Oxaprozin
- Feldene - Generic: Piroxicam
- Relafen - Generic: Nabumetone
- Paracetamol - Generic: Acetaminophen
- Ponstel - Generic: Mefanamic Acid
- Toradol - Generic: Ketorolac
- Vioxx - Generic: Rofecoxib
- Voltaren - Generic: Diclofenac
- Voltaren - Generic: Diclofenac also may inhibit phospholipase A2 as part of its mechanism of action.
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- MScontin, Oramorph, Sevredol - Generic: Morphine (opioid receptor agonist)
- Demerol - Generic: Meperidine (opioid receptor agonist)
- Dolophine - Generic: Methadone (Levomethadone (the R enantiomer) is a opioid receptor agonist)
- Actiq, Duragesic, Fentora - Generic: Fentanyl (opioid receptor agonist)
- Narcan - Generic: Naloxone (competitive opioid receptor antagonist)
- ReVia - Generic: Naltrexone (competitive opioid receptor antagonist)
- Entereg - Generic: Alvimopan (opioid receptor antagonist)
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References
- ↑ http://www.npr.org/blogs/health/2010/09/03/129626052/a-portrait-of-health-prescription-drugs-in-america
- ↑ Overington JP, Al-Lazikani B, Hopkins AL. How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. PMID:17139284 doi:10.1038/nrd2199
- ↑ Peeters MC, van Westen GJ, Li Q, IJzerman AP. Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation. Trends Pharmacol Sci. 2011 Jan;32(1):35-42. PMID:21075459 doi:10.1016/j.tips.2010.10.001