Protein patched homolog 1
From Proteopedia
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3D Structures of protein patched homolog 1
Updated on 11-January-2023
Domains: ectodomain 1 139-428; ectodomain 2 772-1023
6dmb, 6oeu – hPtch1 – human - Cryo EM
6dmo – hPtch1 (mutant) - Cryo EM
6rvd – hPtch1 + sonic hedgehog protein - Cryo EM
6dmy, 6e1h, 6n7g, 6n7h, 6n7k, 6oev, 6rmg – hPtch1/GFP + sonic hedgehog protein - Cryo EM
6rtx – hPtch1 ectodomain 1
6rty – hPtch1 ectodomain 1 + nanobody
6rtw – hPtch1 ectodomain 1 + nanobody + cholesterol derivative
6rvc – hPtch1 ectodomain 2 + nanobody
6mg8 – Ptch1 + ligand – mouse - Cryo EM
7v6y – mPtch1 – mouse - Cryo EM
7v6z – mPtch1 (mutant) - Cryo EM
7k65 – mPtch1 + nanobody - Cryo EM
References
- ↑ Villavicencio EH, Walterhouse DO, Iannaccone PM. The sonic hedgehog-patched-gli pathway in human development and disease. Am J Hum Genet. 2000 Nov;67(5):1047-54. doi: 10.1016/S0002-9297(07)62934-6. Epub , 2000 Sep 21. PMID:11001584 doi:http://dx.doi.org/10.1016/S0002-9297(07)62934-6
- ↑ Ming JE, Kaupas ME, Roessler E, Brunner HG, Golabi M, Tekin M, Stratton RF, Sujansky E, Bale SJ, Muenke M. Mutations in PATCHED-1, the receptor for SONIC HEDGEHOG, are associated with holoprosencephaly. Hum Genet. 2002 Apr;110(4):297-301. doi: 10.1007/s00439-002-0695-5. Epub 2002 Mar, 2. PMID:11941477 doi:http://dx.doi.org/10.1007/s00439-002-0695-5
- ↑ Jeng KS, Sheen IS, Jeng WJ, Lin CC, Lin CK, Su JC, Yu MC, Fang HY. High expression of patched homolog-1 messenger RNA and glioma-associated oncogene-1 messenger RNA of sonic hedgehog signaling pathway indicates a risk of postresection recurrence of hepatocellular carcinoma. Ann Surg Oncol. 2013 Feb;20(2):464-73. doi: 10.1245/s10434-012-2593-y. Epub 2012 , Aug 22. PMID:22911366 doi:http://dx.doi.org/10.1245/s10434-012-2593-y
- ↑ Qian H, Cao P, Hu M, Gao S, Yan N, Gong X. Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nat Commun. 2019 May 24;10(1):2320. doi: 10.1038/s41467-019-10234-9. PMID:31127104 doi:http://dx.doi.org/10.1038/s41467-019-10234-9
