Rabphilin

From Proteopedia

Structure of rabphilin-3A C2B domain (green, grey, pink) complex with SNAP-25 N-terminal helix (yellow, magenta), glycerol, sulfate and Ca+2 ions (PDB code 5lob)

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3D Structures of rabphilin 3-A

Updated on 05-October-2023

Domains: C2A 378-510; C2B 541-680

2cm5, 2cm6 – rRab C2B domain – rat
3rpb, 4izk – rRab C2B domain - NMR
5lo8 – rRab C2B domain + inositol phosphate derivative
5lob, 5low – rRab C2B domain + SNAP25
2chd, 4lt7 – rRab C2A domain
4np9, 4ns0 – rRab C2A domain + inositol phosphate derivative
1zbd – rRab 19-217 (mutant) + rRab effector domain 40-179 (mutant) + GTP
2k3h – mRab C2A domain - mouse - NMR

References

↑ Stanic J, Carta M, Eberini I, Pelucchi S, Marcello E, Genazzani AA, Racca C, Mulle C, Di Luca M, Gardoni F. Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex. Nat Commun. 2015 Dec 18;6:10181. doi: 10.1038/ncomms10181. PMID:26679993 doi:http://dx.doi.org/10.1038/ncomms10181
↑ Iwama S, Sugimura Y, Kiyota A, Kato T, Enomoto A, Suzuki H, Iwata N, Takeuchi S, Nakashima K, Takagi H, Izumida H, Ochiai H, Fujisawa H, Suga H, Arima H, Shimoyama Y, Takahashi M, Nishioka H, Ishikawa SE, Shimatsu A, Caturegli P, Oiso Y. Rabphilin-3A as a Targeted Autoantigen in Lymphocytic Infundibulo-neurohypophysitis. J Clin Endocrinol Metab. 2015 Jul;100(7):E946-54. doi: 10.1210/jc.2014-4209. Epub, 2015 Apr 28. PMID:25919460 doi:http://dx.doi.org/10.1210/jc.2014-4209
↑ Ferrer-Orta C, Perez-Sanchez MD, Coronado-Parra T, Silva C, Lopez-Martinez D, Baltanas-Copado J, Gomez-Fernandez JC, Corbalan-Garcia S, Verdaguer N. Structural characterization of the Rabphilin-3A-SNAP25 interaction. Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5343-E5351. doi:, 10.1073/pnas.1702542114. Epub 2017 Jun 20. PMID:28634303 doi:http://dx.doi.org/10.1073/pnas.1702542114