Reticuline oxidase
From Proteopedia
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3D Structures of Reticuline oxidase
Updated on 02-February-2021
3d2h, 3d2j – CpRO + FAD – California poppy
3fw7, 3fw8, 4pzf – CpRO (mutant) + FAD
3d2d – CpRO + FAD + reticuline
3fwa, 4ec3 – CpRO (mutant) + FAD + reticuline
3fw9, 3gsy – CpRO + FAD + scoulerine derivative
3d2h – CpRO + FAD + ADP derivative
References
- ↑ Dittrich H, Kutchan TM. Molecular cloning, expression, and induction of berberine bridge enzyme, an enzyme essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogenic attack. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):9969-73. PMID:1946465
- ↑ Kutchan TM, Dittrich H. Characterization and mechanism of the berberine bridge enzyme, a covalently flavinylated oxidase of benzophenanthridine alkaloid biosynthesis in plants. J Biol Chem. 1995 Oct 13;270(41):24475-81. doi: 10.1074/jbc.270.41.24475. PMID:7592663 doi:http://dx.doi.org/10.1074/jbc.270.41.24475
- ↑ Morais LC, Barbosa-Filho JM, Almeida RN. Central depressant effects of reticuline extracted from Ocotea duckei in rats and mice. J Ethnopharmacol. 1998 Aug;62(1):57-61. doi: 10.1016/s0378-8741(98)00044-0. PMID:9720612 doi:http://dx.doi.org/10.1016/s0378-8741(98)00044-0
- ↑ Winkler A, Lyskowski A, Riedl S, Puhl M, Kutchan TM, Macheroux P, Gruber K. A concerted mechanism for berberine bridge enzyme. Nat Chem Biol. 2008 Dec;4(12):739-41. Epub 2008 Oct 26. PMID:18953357 doi:http://dx.doi.org/10.1038/nchembio.123
