Retroviral integrase 3D structures

3os0, 3os1, 3os2, 3oy9, 3l2q, 3l2r, 4e7j, 4e7k, 4e7l, 5uoq, 5uop, 5no1, 5mmb, 5mma, 5fro, 5frm, 4ztj, 4ztf – intasome – human spumaretrovirus

3l2u, 3l2v, 3l2w,3oya, 3oyb, 3oyc, 3oyd, 3oye, 3oyf, 3oyg, 3oyh, 3oyi, 3oyj, 3oyk, 3oyl, 3oym, 3oyn, 4be0, 4be1, 4ztf, 4ztj, 5frm, 5frn, 5fro, 5mma, 5mmb, 5no1, 5uop, 5uoq, 7adu, 7adv – intasome + inhibitor

2x6n, 2x6s, 2x74, 2x78, 3dlr - IN catalytic core domain

6rny – intasome + nucleosome – Cryo EM

3s3m, 4e7h – IN + DNA

3kkr, 3kks – IN catalytic core domain – BIV

6u8q, 6vdk – intasome – Cryo EM

1itg, 4dmn, 5oi5, 5oi3, 5oi2, 6jcg, 6jcf, 6vrg, 8wf7 – IN catalytic core domain

3lpt, 3lpu, 3l3u, 1exq, 1b92, 1b9d, 1b9f, 1bi4, 1bhl, 1bl3, 1bis, 1biu, 1biz, 2itg, 3zcm, 5jl4, 6l0c, 6vrg - IN catalytic core domain (mutant) – HIV-1

6t6e, 6t6i, 6t6j – IN catalytic C-terminal domain

3l3v - IN catalytic core domain (mutant) + sucrose

1k6y - IN N-terminal + catalytic core domain

1wje, 1wjf - IN N-terminal zinc-binding domain (mutant) – NMR

1wja, 1wjb, 1wjc, 1wjd - IN N-terminal zinc-binding domain

1ex4 - IN C-terminal DBD + catalytic core domain (mutant)

1ihv, 1ihw – IN DBD - NMR

1qmc – IN DBD - NMR

2b4j, 3av9, 3ava, 3avb, 3avc, 3avf, 3avg, 3avh, 3avi, 3avj, 3avk, 3avl, 3avm, 3avn, 1qs4 - IN CCD domain (mutant) + lens epithelium-derived growth factor

8cbt, 8cbv - IN CCD domain + inhibitor

3ao5 - IN 765-927 + inhibitor

4ahr, 4ahs, 4aht, 4ahu - IN CCD domain (mutant) + inhibitor

1hyv, 1hyz, 4cer, 4chp, 4chy, 4o0j, 5krt, 5krs, 5kgx, 5kgw, 6ex9, 6um8, 6vkh, 6vlh, 6vlm, 6vqs, 6vx2, 6w0u, 6w42, 6wc8, 6we7, 7d83, 7ke0, 7l1p, 7l23, 7l2y, 7lqp, 7rq0, 7sia, 7t9h, 7t9o, 7u2u, 7uoq, 7wce, 8bv2, 8cbr – IN catalytic core domain + inhibitor

1qs4, 3nf6, 3nf7, 3nf8, 3nf9, 3nfa, 3zsv, 3zsx, 3zt2, 4ceb, 4ces, 4cf9, 4chq, 4cj4, 4cjt, 4cju, 4e1m, 4e1n, 4jlh, 4lh4, 4nyf, 4o55, 4o5b, 4ojr, 4ovl, 4tsx, 5hrs, 5hrr, 5hrp, 5hrn, 5hot, 6eb1, 6eb2, 6lmi, 6lmq, 6ncj, 6nuj, 6vka, 7ue1, 8ct7, 8d3s - IN core domain (mutant) + inhibitor

8a1p, 8cbs, 8cbu, 8cta – IN catalytic core+ C-terminal domains + inhibitor

8a1q – IN catalytic core+ C-terminal domains + drug

5tc2 – IN C terminal

5eu7 – IN catalytic core domain + antibody

3wne, 3wnh, 4y1d, 4y1c – IN catalytic core domain + peptide

8fn7, 8fnd, 8fng, 8fnh, 8fnj, 8fnl, 8fnm, 8fnn, 8fno, 8fnp, 8fnq – IN intasome (mutant) + drug

6qbt – IN catalytic core domain

3f9k - IN N-terminal + catalytic core domain + LEDGF IBD – HIV-2

1e0e - IN N-terminal – NMR

6qbv, 6qbw – IN catalytic core domain

6tju – IN C-terminal domain

3nnq, 4nzg – IN N-terminal – MOMLV

2m9u – IN C-terminal domain - NMR

7jyz – IN C-terminal domain + hBrd3 - NMR

3hpg, 3hph – IN N-terminal + catalytic core domain + LEDGF IBD – MVV

5t3a – IN

5llj – IN C terminal

5m0r, 7zpp, 7u32 – intasome – Cryo EM

1c6v – IN catalytic domain (mutant) + DNA binding domain - SIV

6rwl – intasome – Cryo EM

6rwo – intasome (mutant) + drug – Cryo EM

6rwl – intasome + PP2A regulatory subunit – Cryo EM

7ouf, 7ouh – intasome (mutant) + B56 + DNA – Cryo EM

7oug – intasome (mutant) + B56 + DNA + drug – Cryo EM

4pa1 - IN catalytic core domain - FIV

4mq3 – IN catalytic core domain (mutant)

5cz1 – IN catalytic domain

1c0m, 1c1a – IN fragment (mutant) – RSV

1vsk, 1vsl, 3o4q - IN catalytic core domain (mutant)

1vsm, 1vsh, 1vsi, 1vsj, 1vsd, 1vse, 1vsf, 3o4n - IN catalytic core domain

1a5v, 1a5w, 1a5x - IN catalytic core domain + inhibitor

5ejk – intasome + gag-pro-pol polyprotein

7ku7, 7kui, 8e14 – intasome – Cryo EM

7jn3 – intasome (mutant) + drug – Cryo EM

1cxq, 1cxu, 1cz9, 1czb, 1asu, 1asv, 1asw - IN catalytic core domain (mutant) – ASV

5cz1 – IN catalytic domain 1487-1648

7usf, 7ut1 – IN 1437-1755 + DNA – Cryo EM

3vcf – IN C-terminal catalytic domain

3nkh – IN fragment – Staphylococcus aureus MRSA

1b69, 1tn9 - EfIN N-terminal DBD + DNA – Enterococcus faecalis – NMR

1bb8, 2bb8 - EfIN N-terminal DBD – NMR

3nrw – IN/site-specific recombinase N-terminal – Haloarcula marismortui

3jtz – IN arm-type binding domain – Yersinia pestis

3ju0 – HPI IN arm-type binding domain – Pectobacterium atrosepticum

8fti – IN (mutant) + RNA – Planctomycetota bacterium – Cryo EM

2kkp – IN SAM-like domain – Moorella thermoacetica – NMR

2kkv – IN fragment – Salmonella enterica – NMR

2khq - IN fragment – Staphylococcus saprophyticus – NMR

2khv, 2kj5 – INT residues 102-199 – Nitrosospira multiformis – NMR

2a3v – Rec INTI4+DNA – Vibrio cholera

1z19, 1z1b, 1z1g, 1p7d – EpLamInt catalytic core domain+DNA

6emy, 6emz, 6en0, 6en1, 6en2 – IN (mutant) + DNA – Enterococcus faecalis

3bvp – IN N-terminal – Lactococcus phage

1aih – HP1 IN catalytic domain – bacteriophage

5dor, 5c6k – IN catalytic domain – Enterobacteria phage P2

2wcc, 1kjk – λIN DBD+ DNA – Enterobacteria phage λ - NMR

2oxo – λIN residues 75-176

1ae9 – λIN catalytic core

5j0n – λIN + ATTP + ATTB + integration host factor + excisionase - Cryo EM

5uae, 5udo – IN coiled-coil domain – Listeria innocua phage

1p4e, 1m6x]] – FLP (mutant)+DNA

1flo - FLP +DNA

7z0h, 7z2z, 7z30, 7z31 – IN + Pol III + DNA – Cryo EM